Cossarizza / Kaplan Cellular Aspects of HIV Infection

1. Auflage 2003
ISBN: 978-0-471-45915-6
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 472 Seiten, E-Book

Reihe: Cytometric Cellular Analysis

Cellular Aspects of HIV Infection provides a highly readable,detailed overview of the state of the art in modern HIV research atthe cellular level. This volume brings together renowned expertswho have provided concise, synthetic treatments of the biology ofHIV infection. It presents these descriptions and analyses withparticular attention to the techniques of flow cytometry that haveallowed us to not only observe the course of HIV infection and theimmune system's response to it, but have also increased our abilityto treat patients and understand their response to therapy.
The book is divided into five sections covering molecules andcells, pathophysiological processes, technologies, and organisms. Aperspective on future therapies concludes the book. Each chapteroffers an intelligent, concise synthesis of the topic, highlightingthe biological principles and technologies involved in the study ofHIV infection. Cellular Aspects of HIV Infection is anindispensable, up-to-date guide for immunologists, virologists,clinicians, and researchers.

Autoren/Hrsg.

Cossarizza, Andrea

Kaplan, David

Inhaltsverzeichnis

Preface.
Contributors.
Part I: MOLECULES.
1. HIV and Molecular Biology of the Virus-Host Interplay (MassimoClementi).
2. Telomere Length, CD28 T Cells, and HIV DiseasePathogenesis (Rita B. Effros).
3. Immune Dysregulation and T-Cell Activation Antigens in HIVInfection (Mara Biasin, Fulvia Colombo, Stefania Piconi, and MarioClerici).
4. Quantification of HIV/SIV Coreceptor Expression (Benhur Lee andRobert W. Doms).
Part II: CELLS.
5. B Cells in the Line of Sight of HIV-1 (Yolande Richard, Eric A.Lefèvre, Roman Krzysiek, Christophe Legendre, DominiqueDormont, Pierre Galanaud, and Gabriel Gras).
6. Cytotoxic T-Cell (CTL) Function in HIV Infection (M. L. Garbaand J. A. Frelinger).
7. Analysis of the /
T-Cell Receptor Repertoire in HIV Infection (Hugo Soudenys).
8. Gamma-Delta () T Cells and HIV-1 Infection (Roxana E. Rojas andW. Henry Boom) 9. Natural Killer Cells in HIV Infection and Role inthe Pathogenesis of AIDS (Benjamin Bonavida).
10. Alveolar Macrophages (Jianmin Zhang and Henry Koziel).
11. Dendritic Cells Ferry HIV-1 from Periphery into LymphoidTissues (Teunis B. H. Geijtenbeek and Yvette van Kooyk).
Part III: PROCESSES.
12. Homeostasis and Restoration of the Immune System in HAARTTreated HIV-Infected Patients: Implications of Apoptosis(Marie-Lise Gougeon, Hervé LeCoeur, Luzia Maria de OliveiraPinto, and Eric Ledru).
13. Mitochondria Functionality During HIV Infection (AndreaCossarizza, Marcello Pinti, Milena Nasi, Maria Garcia Fernandez,Laura Moretti, Cristina Mussini, and Leonarda Troiano).
14. Multiple Roles of Cytokines in HIV Infection, Replication, andTherapy (Massimo Alfano and Guido Poli). Part IV:TECHNOLOGIES.
15. The Use of Peptide/MHC Tetramers to Visualize, Track, andCharacterize Class I-Restricted Anti-HIV T-Cell Response (Clive M.Gray and Thomas C. Merigan).
16. Tagging of HIV with Green Fluorescent Protein (Nadya I.Tarasova).
17. Flow Cytometric Analysis of Cells from Persons with HIV-1Disease by Enzymatic Amplification Staining (David Kaplan).
18. Antigen-Specific Cytokine Responses in HIV Disease (Vernon C.Maino, Holden T. Maecker, and Louis J. Picker).
Part V: ORGANISMS.
19. Chimeric Models of SCID Mice Transplanted with Human Cells: TheHu-PBL-SCID Mouse and Its Use in AIDS Research (S. M. Santini, C.Lapenta, M. Logozzi, S. Parlato, M. Spada, T. Di Pucchio, S. Fais,and F. Belardelli).
20. Immune Reconstitution of the CD4 T-Cell Compartment in HIVInfection (Guislaine Carcelain, Taisheng Li, Marc Renaud, PatriceDebré, and Brigitte Autran).
21. New Perspectives in Antiretroviral Therapy of HIV Infection(Stefano Vella).
Index.