Finkel / Gutkind Signal Transduction and Human Disease

1. Auflage 2003
ISBN: 978-0-471-44837-2
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 488 Seiten, E-Book

This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.

Autoren/Hrsg.

Finkel, Toren

Gutkind, J. Silvio

Inhaltsverzeichnis

Acknowledgments.
Contributors.
Introduction.
1. Atherosclerosis: Signal Transduction by Oxygen and NitrogenRadicals (Jonathan M. Hill, Ilsa I. Rovira, and Toren Finkel).
2. NF-kB:A Key Signaling Pathway in Asthma (Stewart J.Levine).
3. Molecular Mechanisms of Cancer (Akrit Sodhi, Silvia Montaner,and J. Silvio Gutkind).
4. Apoptotic Pathways in Cancer Progression and Treatment (JoyaChandra and Scott H. Kaufmann).
5. Molecular and Cellular Aspects of Insulin Resistance:Implications for Diabetes (Derek Le Roith, Michael J. Quon, andYehiel Zick).
6. Dysfunction of G Protein-Regulated Pathways and EndocrineDiseases (William F. Simonds).
7. Bacterial Regulation of the Cytoskeleton (Jeremy W. Peck,Dora C. Stylianou, and Peter D. Burbelo).
8. Bacterial Toxins and Diarrhea (Walter A. Patton, Joel Moss,and Martha Vaughan).
9. Molecular Basis of Severe Combined Immunodeficiency: Lessonsfrom Cytokine Signaling Pathways (Roberta Visconti, Fabio Candotti,and John J. O'Shea).
10. Mast Cell-Related Diseases: Genetics, Signaling Pathways,and Novel Therapies (Michael A. Beaven and Thomas R. Hundley).
11. Rheumatology and Signal Transduction (Keith M. Hull andDaniel L. Kastner).
12. Molecular Mechanisms of Neurodegenerative Disorders(Benjamin Wolozin).
13. Neurotrophic Signaling in Mood Disorders (Jing Du,Todd D.Gould, and Husseini K. Manji).
14. Inhibiting Signaling Pathways Through Rational Drug Design(James N.Topper and Neill A. Giese).
Index.

Über Autor(innen)

Dr. Toren Finkel is Chief of the Cardiovascular Branch,National Heart Lung and Blood Institute, National Institutes ofHealth (NIH, DHHS). He received his undergraduate training inphysics and then completed a combined M.D./Ph.D. program at HarvardMedical School. Following graduation he pursued an internal medicalresidency at the Massachusetts General Hospital in Boston and aCardiology Fellowship at Johns Hopkins School of Medicine inBaltimore. His laboratory has been interested in the role ofoxidants as signaling molecules and the participation of freeradicals in human disease.
Dr. J. Silvio Gutkind is Chief of the Oral and PharyngealCancer Branch, National Institute of Dental and CraniofacialResearch, National Institutes of Health (NIH, DHHS). He receivedhis Ph.D. in pharmacy and biochemistry from the University ofBuenos Aires, Argentina. His laboratory has addressed the molecularbasis of cancer by studying normal and aberrant functions ofmolecules involved in the transduction of proliferative signals. Healso leads a multi-institutional effort aimed to elucidate themolecular changes that contribute to the evolution of squamous cellcarcinomas.