Heida / Marani / Usunoff The Subthalamic Nucleus

Part II: Modelling and Simulation of Activity
1. Auflage 2008
ISBN: 978-3-540-79462-2
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 199, 88 Seiten, eBook

Reihe: Advances in Anatomy, Embryology and Cell Biology

Part II starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs, and high frequency stimulation. STN bursting activity and the underlying ionic mechanisms are investigated. Deep brain stimulation used for symptomatic treatment of Parkinson’s disease is discussed in terms of the elements that are influenced and its hypothesized mechanisms. This part of the monograph pays attention to the pedunculopontine-subthalamic connections and tries in cell cultures to mimic neurotransmitter actions of the pedunculopontine nucleus and high frequency stimulation on cultured dissociated rat subthalamic neurons. STN cell models: single and multi compartment, and system level models are discussed in relation to subthalamic function and dysfunction. Part I and II are mutually compared.

Zielgruppe

Research

Autoren/Hrsg.

Heida, Tjitske

Marani, Enrico

Usunoff, Kamen G.

Inhaltsverzeichnis

The Basal Ganglia.- STN Activity Recorded in Vitro: Brain Slices.- STN Activity Recorded in Vitro: Dissociated Cell Cultures.- STN Cell Models and Simulation of Neuronal Networks.- Comparison of Part I and Part II.