Houghton / Arceci Molecularly Targeted Therapy for Childhood Cancer

1. Auflage 2010
ISBN: 978-0-387-69062-9
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 536 Seiten, eBook

Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered.This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.

Zielgruppe

Research

Autoren/Hrsg.

Houghton, Peter

Arceci, Robert

Houghton, Peter J.

Arceci, Robert J.

Inhaltsverzeichnis

Hematologic Malignancies.- The Emerging Era of Targeted Therapy in Childhood Acute Lymphoblastic Leukemia.- Molecular Targeted Therapies in T-Cell Acute Lymphoblastic Leukemia.- Molecularly Targeted Therapy for Infant ALL.- Targeted Therapeutic Approaches for AML.- Acute Promyelocytic Leukaemia.- Down Syndrome and Acute Myeloid Leukemia: An Unique Genetic Sensitivity to Chemotherapy.- Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia (JMML).- Chronic Myeloid Leukemia: Pathophysiology and Therapeutics.- Molecularly Targeted Therapies in Pediatric Myelodysplastic Syndromes.- New Therapeutic Frontiers for Childhood Non-Hodgkin Lymphoma.- Molecular Targeting of Post-transplant Lymphoproliferative Disorders.- Solid Tumors.- Molecularly Targeted Therapies for Astrocytomas.- Targeted Therapy in Medulloblastoma in Molecularly Targeted Therapy for Childhood Cancer.- Future Treatments of Ependymoma.- Development of Targeted Therapies for Rhabdoid Tumors Based on the Functions of INI1/hSNF5 Tumor Suppressor.- Development of Targeted Therapies for Neurofibromatosis Type 1 (NF1) Related Tumors.- Molecular Therapy for Neuroblastoma.- Ewing’s Sarcoma Family of Tumors: Molecular Targets Need Arrows.- Molecular Targeted Therapy for Wilms’ Tumor.- Molecular Therapy for Rhabdomyosarcoma.- Molecularly Targeted Therapy for Osteosarcoma: Where Do We Go from Here?.- Nonrhabdomyosarcoma Soft Tissue Sarcoma in Children: Developing New Treatments Based on a Better Understanding of Disease Biology.