Automated Sample Preparation

Methods for GC-MS and LC-MS
1. Auflage 2021
ISBN: 978-3-527-34507-6
Verlag: Wiley-VCH GmbH

Buch, Englisch, 480 Seiten, Format (B × H): 175 mm x 247 mm, Gewicht: 1052 g

An essential guide to the proven automated sample preparation process

While the measurement step in sample preparation is automated, the sample handling step is manual and all too often open to risk and errors. The manual process is of concern for accessing data quality as well as producing limited reproducibility and comparability.

Handbook of Automated Sample Preparation for CG-MS and LC-MS explores the advantages of implementing automated sample preparation during the handling phase for CG-MS and LC-MS. The author, a noted expert on the topic, includes information on the proven workflows that can be put in place for many routine and regulated analytical methods.

This book offers a guide to automated workflows for both on-line and off-line sample preparation. This process has proven to deliver consistent and comparable data quality, increased sample amounts, and improved cost efficiency. In addition, the process follows Standard Operation Procedures that are essential for audited laboratories. This important book:

- Provides the information and tools needed for the implementation of instrumental sample preparation workflows
- Offers proven and detailed examples that can be adapted in analytical laboratories
- Shows how automated sample preparation can reduce cost per sample, increase sample amounts, and produce faster results
- Includes illustrative examples from various fields such as chemistry to food safety and pharmaceuticals

Written for personnel in analytical industry, pharmaceutical, and medical laboratories, Handbook of Automated Sample Preparation for CG-MS and LC-MS offers the much-needed tools for implementing the automated sample preparation for analytical laboratories.

Autoren/Hrsg.

Hübschmann, Hans-Joachim

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Lebensmitteltechnologie und Getränketechnologie
• Naturwissenschaften Chemie Analytische Chemie Umweltchemie, Lebensmittelchemie

Inhaltsverzeichnis

1. Introduction
 
2. The Analytical Process
2.1 Laboratory Logistics
 
3. Workflow Concepts
3.1 Sample Preperation Workflow Design
3.2 Instrumental Concepts
3.3 Sample Processing
3.4 Tool Change
3.5 Object Transport
3.6 Vial Decapping
 
4. Analytical Aspects
4.1 Liquid Handling
4.2 Solid Materials Handling
4.3 Weighing
4.4 Extraction
4.5 Clean-Up Procedures
4.6 Centrifugation
4.7 Evaporation
4.8 Deriatization
4.9 Temperature Control
4.10 Mixing
 
5. Integration into Analysis Techniques
5.1 GC Volatiles Analysis
5.2 GC Liquid Injection
5.3 LC-GC Online Injection
5.4 LC Injection
 
6. Solutions for Automated Analysis
6.1 Dilution
6.2 Derivatization
6.3 Taste and Odor Compounds Trace Analysis
6.4 Sulfur Compounds in Tropical Fruits
6.5 Ethanol Residues in Halal Food
6.6 Volatile Organic Compounds in Drinking Water
6.7 Geosmin in 2-MIB
6.8 Solvent Elution from Charcoal
6.9 Semivolatile Organic Compounds
6.10 Polyaromatic Hydrocarbons in Drinking Water
6.11 Fatty Acid Methylester
6.12 MCPD andGlycidol in Vegetable Oil
6.13 Mineral Oil Hydrocarbons MOSH/MOAH
6.14 Pesticides Analysis - QuEChERS Extract Clean-Up
6.15 Glyphosate, AMPA, and Glufosinate by Online SPE-LC-MS
6.16 Pesticides, PPCPs, and PAHs by Online SPE-Water Analysis
6.17 Residual Solvents
6.18 Chemical Warfare Agents in Water and Soil
6.19 Shale Aldehydes in Beer
6.20 Phthalates in Polymers
 
A. Appendix
A.1 Robotic System Control
A.2 System Maintenance
A.3 Syringe Needle Gage
A.4 Pressure Units Conversion
A.5 Solvents
A.6 Material Resistance

Über Autor(innen)

Hans-Joachim Hübschmann graduated as Certified Food Chemist from the Technical University in Berlin, Germany, working on residue analysis of anabolic agents and pesticides in foods. He started his career in diagnostics, medical analytical instruments and application development working for a number of German companies in chromatography, mass spectrometry and in biotechnology. He joined Thermo Fisher Scientific in Bremen, Germany, and held several international positions covering inorganic and isotope ratio mass spectrometry specializing in food safety, forensic and dioxin analysis. In 2015 he established the independent consulting agency HANS Analytical Solutions for the development of automated sample preparation workflows. In his current capacity he is located in Osaka, Japan, as the Vice President Sales of CTC Analytics for the emerging Asia/Pacific region.