Neuroimmune Pharmacology

2008
ISBN: 978-0-387-72572-7
Verlag: Springer

Buch, Englisch, 828 Seiten, Book, Format (B × H): 210 mm x 279 mm, Gewicht: 2348 g

Neuroimmune pharmacology seeks to harness the immune system to provide pharmacological intervention to combat neurodegenerative diseases. This book provides a comprehensive overview of topics that embrace the link between the immune system and the pathogenesis of neurodegenerative disorders. Results from recent studies strongly suggest that a major part of the process in diseases including Alzheimer’s and Parkinson’s as well as Prion diseases, comes from changes in the innate and adaptive arms of the brain and peripheral immune systems. Thus, the book provides an in-depth study of numerous fields including immunology, pharmacology, neuroscience and neurovirology. It is accompanied by a CD-ROM that includes access to lectures, slide presentations, and question and answers on neuroimmune pharmacology.

Zielgruppe

Research

Autoren/Hrsg.

Ikezu, Tsuneya

Gendelman, Howard

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

Immunology of the Nervous System.- Introducing Neuroimmune Pharmacology.- Innate and Adaptive Immunity in Health and Disease.- Anatomical Networks: Structure and Function of the Nervous System.- The Blood Brain Barrier.- Anterior Chamber and Retina.- Hippocampus and Spatial Memory.- Glial and Neuronal Cellular Compostion, Biology, and Physiology.- Astrocytes, Oligodendrocytes, and Schwann Cells.- Macrophages, Microglia, and Dendritic C.- Neuronal and Glial Signaling.- The Vertebrate Retina.- Lymphocytes and the Nervous System.- Stem Cells.- Neurobiology and Neural Systems.- Cytokines and Chemokines.- CNS Cell Signaling.- Nervous System Diseases and Immunity: Clinical Descriptions.- Neurodegeneration.- Multiple Sclerosis and Other Demyelinating Diseases.- Guillain-Barré Syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, and Axonal Degeneration and Regeneration.- Guillain-Barré Syndrome.- Autoimmune Disease.- NeuroAIDS.- HTLV-I/II.- Viral Encephalitis.- Alzheimer's Disease.- Parkinson's Disease.- Amyotrophic Lateral Sclerosis.- Huntington's Disease.- Prion Diseases.- Glaucoma.- Stroke and Cerebrovascular Disease.- Neurogenesis and Brain Repair.- Familial Neurodegenerative Diseases and Single Nucleotide Polymorphisms.- The Neuroimmune System in Psychiatric Disorders.- Major Depression, Bipolar Syndromes, and Schizophrenia.- Molecular Pathogenesis for Schizophrenia and Major Depression.- Drugs of Abuse and the Immune System.- Therapeutics.- Neuropharmacology.- Neurodegenerative Diseases.- Multiple Sclerosis.- HIV-Associated Dementia.- Immunotherapy.- Alzheimer's Disease.- Parkinson's Disease and Amyotrophic Lateral Sclerosis.- Protective and Regenerative Autoimmunity in CNS Injury.- Adjuvants.- Polymer Nanomaterials.- Gene Therapy and Vaccination.- Proteomics and Genomics.- Neuroimaging.

Über Autor(innen)

Tsuneya Ikezu, M.D., Ph.D.

Associate Professor, Department of Pharmacology and Experimental Neuroscience

Associate Director, Center for Neurovirology and Neurodegenerative Disorders

Description: Dr. Ikezu was born in Tokyo, Japan, obtained MD-PhD (Clinical Pharmacology in Major) from University of Tokyo School of Medicine, and had post-doctoral training at UCSF (Immunology), Harvard Medical School (Clinical Pharmacology), and Cleveland Clinic Foundation (Neuroscience). He is currently Associate Professor of Pharmacology and Experimental Neuroscience, and Associate Director of Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center

Howard E. Gendelman, M.D.

Larson Professor of Internal Medicine and Infectious Diseases

Chair, Department of Pharmacology and Experimental Neuroscience

Director, Center for Neurovirology and Neurodegenerative Disorders

Dr. Howard Gendelman is the Larson Professor of Medicine and Chair of the Department of Pharmacology and Experimental Neuroscience and Director of the Center for Neurovirology and Neurodegenerative Disorders at the University of Nebraska Medical Center. He received his medical degree from Pennsylvania State University followed by fellowship training and faculty appointments at the Albert Einstein College of Medicine, the Johns Hopkins University Medical Center, the National Institutes of Health, and the Walter Reed Army Institute of Research. He has gained international attention for his work on common mechanisms of nerve damage in Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and HIV-1-associated dementia. His research has lead to groundbreaking discoveries on how inflammation causes nerve cell damage and how drugs and vaccines can be used to reverse it.