Ikezu / Gendelman Neuroimmune Pharmacology

1. Auflage 2008
ISBN: 978-0-387-72573-4
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 878 Seiten, eBook

In the past two decades, enormous strides have been made These tools for exploring brain biochemistry at the cellular in our understanding of the relationships between inflamma- level opened new vistas for understanding brain functioning tion, innate immune responses, adaptive immune responses, and the pathogenesis of human disease. Using these tools, and degenerative human diseases. The developing informa- our laboratory and that of Joseph Rogers in Sun City d- tion has mostly appeared in specialty journals that have dealt onstrated that HLA-DR was strongly expressed on activated only with isolated aspects of these tightly related fields. As microglia. The identification of HLA-DR, a well-known a result, contemporary scientists have had a difficult time leukocyte marker displayed by antigen presenting cells, on finding sources, even in review articles, that provide an these cells vindicated both Hortega and van Furth. The way integrated picture. This volume, by assembling chapters waspaved for many productive investigations exploring the that demonstrate the relationship between these historically properties of microglial cells and their relationship to infl- separated fields, overcomes that difficulty. There are sec- mation and immune responses. This example of a conju- tions on immunology of the nervous system, diseases that tion between a fundamental concept and technical advances result from immunological dysfunction, current therapeutic to establish its validity has been repeated many times since, approaches, and prospects for the future. Overall, it inte- as the chapters in this volume illustrate.

Zielgruppe

Research

Autoren/Hrsg.

Ikezu, Tsuneya

Gendelman, Howard E.

Inhaltsverzeichnis

Immunology of the Nervous System.- Introducing Neuroimmune Pharmacology.- Innate and Adaptive Immunity in Health and Disease.- Anatomical Networks: Structure and Function of the Nervous System.- The Blood Brain Barrier.- Anterior Chamber and Retina.- Hippocampus and Spatial Memory.- Glial and Neuronal Cellular Compostion, Biology, and Physiology.- Astrocytes, Oligodendrocytes, and Schwann Cells.- Macrophages, Microglia, and Dendritic C.- Neuronal and Glial Signaling.- The Vertebrate Retina.- Lymphocytes and the Nervous System.- Stem Cells.- Neurobiology and Neural Systems.- Cytokines and Chemokines.- CNS Cell Signaling.- Nervous System Diseases and Immunity: Clinical Descriptions.- Neurodegeneration.- Multiple Sclerosis and Other Demyelinating Diseases.- Guillain-Barré Syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, and Axonal Degeneration and Regeneration.- Guillain-Barré Syndrome.- Autoimmune Disease.- NeuroAIDS.- HTLV-I/II.- Viral Encephalitis.- Alzheimer's Disease.- Parkinson's Disease.- Amyotrophic Lateral Sclerosis.- Huntington's Disease.- Prion Diseases.- Glaucoma.- Stroke and Cerebrovascular Disease.- Neurogenesis and Brain Repair.- Familial Neurodegenerative Diseases and Single Nucleotide Polymorphisms.- The Neuroimmune System in Psychiatric Disorders.- Major Depression, Bipolar Syndromes, and Schizophrenia.- Molecular Pathogenesis for Schizophrenia and Major Depression.- Drugs of Abuse and the Immune System.- Therapeutics.- Neuropharmacology.- Neurodegenerative Diseases.- Multiple Sclerosis.- HIV-Associated Dementia.- Immunotherapy.- Alzheimer's Disease.- Parkinson's Disease and Amyotrophic Lateral Sclerosis.- Protective and Regenerative Autoimmunity in CNS Injury.- Adjuvants.- Polymer Nanomaterials.- Gene Therapy and Vaccination.- Proteomics and Genomics.- Neuroimaging.

Über Autor(innen)

Tsuneya Ikezu, M.D., Ph.D.Associate Professor, Department of Pharmacology and Experimental NeuroscienceAssociate Director, Center for Neurovirology and Neurodegenerative DisordersDescription: Dr. Ikezu was born in Tokyo, Japan, obtained MD-PhD (Clinical Pharmacology in Major) from University of Tokyo School of Medicine, and had post-doctoral training at UCSF (Immunology), Harvard Medical School (Clinical Pharmacology), and Cleveland Clinic Foundation (Neuroscience). He is currently Associate Professor of Pharmacology and Experimental Neuroscience, and Associate Director of Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical CenterHoward E. Gendelman, M.D.Larson Professor of Internal Medicine and Infectious DiseasesChair, Department of Pharmacology and Experimental NeuroscienceDirector, Center for Neurovirology and Neurodegenerative DisordersDr. Howard Gendelman is the Larson Professor of Medicine and Chair of the Department of Pharmacology and Experimental Neuroscience and Director of the Center for Neurovirology and Neurodegenerative Disorders at the University of Nebraska Medical Center. He received his medical degree from Pennsylvania State University followed by fellowship training and faculty appointments at the Albert Einstein College of Medicine, the Johns Hopkins University Medical Center, the National Institutes of Health, and the Walter Reed Army Institute of Research. He has gained international attention for his work on common mechanisms of nerve damage in Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and HIV-1-associated dementia. His research has lead to groundbreaking discoveries on how inflammation causes nerve cell damage and how drugs and vaccines can be used to reverse it.