Juurlink / Devon / Doucette Cell Biology and Pathology of Myelin

Evolving Biological Concepts and Therapeutic Approaches
Erscheinungsjahr 2012
ISBN: 978-1-4615-5949-8
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 4, 398 Seiten, eBook

Reihe: Altschul Symposia Series

Zielgruppe

Research

Autoren/Hrsg.

Juurlink, Bernhard H.J.

Devon, Richard M.

Doucette, J. Ronald

Nazarali, Adil J.

Schreyer, David J.

Verge, Valerie M.K.

Inhaltsverzeichnis

Myelin as a Dynamic Structure.- 1. Structure and Function of Myelin, an Extended and Biochemically Modified Cell Surface Membrane.- 2. Myelin Basic Protein, the “Executive” Molecule of the Myelin Membrane.- 3. Myelin-Associated Glycoprotein: Ligand and/or Receptor.- 4. Myelin/Oligodendrocyte Glycoprotein: A Molecular Analysis.- 5. Molecular Biology of Hereditary Motor and Sensory Neuropathies.- 6. Mutations of the Proteolipid Protein Gene: A Molecular Mechanism of CNS Dysmyelination.- 7. Myelin Proteins as Mediators of Signal Transduction.- 8. CNP in Myelination: Overexpression Alters Oligodendrocyte Morphogenesis.- 9. The Role of the Gap Junction Protein Connexin32 in the Myelin Sheath.- 10. The Role of Myelin Po Protein.- Factors Controlling the Expression of the Myelinating Phenotype.- 11. Posttranscriptional Regulation of Myelin Basic Protein Gene Expression.- 12. Molecular Control of Myelin Basic Protein Gene Expression.- 13. Role of cAMP during the Process of Demyelination and Remyelination in Peripheral Nerve.- 14. Characterization of an Axonal Protein Involved in Myelination.- 15. Do Secretory Pathway SNARE Proteins Mediate Myelinogenesis?.- 16. Expression of the PLP Gene and a PLP-LacZ Transgene in Oligodendrocytes.- 17. Developmental Regulation of Schwann Cell Precursors and Schwann Cell Generation.- 18. Protein Kinase C Regulates Process Formation by Oligodendrocytes.- 19. Mechanism of Adhesion-Induced Regeneration/Differentiation of Oligodendrocytes.- 20. A Procedure for Isolating Schwann Cells Developed for Analysis of the Mouse Embryonic Lethal Mutation NF1.- 21. Expansion of Oligodendrocyte Progenitors for Myelin Repair.- 22. Generation of Oligodendrocyte Precursors from Human Neural Cells in Vitro.- Promoting Functional Recovery in White Matter.- 23.Recent Insights into the Cellular Biology of Remyelination: Implications for Multiple Sclerosis.- 24. Characterising the Adult Human Oligodendrocyte Progenitor.- 25. The Repair of Central Nervous System Myelin: Cell Biology and Pharmacologic Action of Remyelination-Promoting Autoantibodies.- 26. Inhibition of Human and Rat Glial Cell Function by Anti-Inflammatory Cytokines, Antioxidants, and Elevators of cAMP.- 27. Oligodendrocytes and Axonal Regrowth: A Double-Edged Sword.- 28. Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells.- 29. Axonal Regeneration in the Fish and Amphibian CNS: Myelin-Associated Neurite Growth Inhibitors and Adaptive Plasticity of Glial Cells.- 30. Role of MAG as an Axon Growth Inhibitory Protein for Regeneration of Injured Neurons in the CNS.- 31. Schwann Cells as Facilitators of Axonal Regeneration in CNS Fiber Tracts.- 32. Olfactory Ensheathing Cells Can Be Induced to Express a Myelinating Phenotype.- 33. Overcoming Myelin-Associated Inhibition of Axonal Regeneration after CNS Injury.- Abstract.- Contributors.