Klein Advances in Cancer Research

1. Auflage 1994
ISBN: 978-0-08-056246-9
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 64, 305 Seiten, Web PDF

Reihe: Advances in Cancer Research

This volume contains reviews highlighting some of the most important achievements in understanding the molecular basis of cancer. Included are reviews on human papilloma virus and tumor suppressor gene products, the function of SH2 and SH3 domains in tyrosine kinase signal transduction, oncogene activation in mammary tumors, the phenotypes of polyoma middle T antigen in transgenic animals, and the role of protein kinase C and FCg receptors in neoplastic disease. Transgenic animal models for the study of molecular events in cancer are especially featured in these reviews.* Highlights of Volume 64:* Interactions of papilloma virus proteins with tumor suppressors* Retinoblastoma tumor suppressor protein* SH2 and SH3 domains in tyrosing kinase signal transduction* Oncogene activation in mammary tumors* Polyomavirus middle T antigen phenotypes in transgenic animals* Protein kinase C and FCg receptors in neoplastic disease* Transgenic mouse models for molecular carcinogenesis

Autoren/Hrsg.

Klein, George

Inhaltsverzeichnis

1;Cover;1
2;Contents;6
3;Contributors to Volume 64;10
4;Chapter 1. Interactions between Papillomavirus Proteins and Tumor Suppressor Gene Products;12
4.1;I. Introduction;12
4.2;II. Human Papillomaviruses;13
4.3;III. Regulation of Cell Growth;16
4.4;IV. Viral/Host Protein Interactions;18
4.5;V. HPV Oncoproteins„Tools and Tarrets;29
4.6;References;30
5;Chapter 2.The Retinoblastoma Tumor Suppressor Protein;36
5.1;I. Overview;36
5.2;II. Mutation of Rb-1 in Tumors;37
5.3;III. Growth-Inhibitory Activity of RB;41
5.4;IV. Cell Cycle-Regulated Phosphorylation of RB;43
5.5;V. Protein-Binding Function of RB;59
5.6;VI. Regulation of RB Function by Phosphorylation;81
5.7;VII. Future Prospects;86
5.8;References;89
6;Chapter 3. SH2 and SH3 Domains in Signal Transduction;98
6.1;I. Protein Tyrosine Kinases and Their Targets;98
6.2;II. SH2 Domains;101
6.3;III. SH3 and PH Domains;109
6.4;IV. Coupling Tyrosine Kinases to Ras;111
6.5;V. SH2-Containing Phosphotyrosine Pliosphatases and the Genetics of Signal Transduction;115
6.6;References;116
7;Chapter 4. Activation of the Src Family of Tyrosine Kinases in Mammary Tumorigenesis;122
7.1;I. Introduction;122
7.2;II. Src Family of Protein Tyrosine Kinases;123
7.3;III. Elevation of c-Src Kinase Activity in Primary Mammary Tumors and Tumor-Derived Cell Lines;128
7.4;IV.Transgenic Mouse Models for Testing the Role of Src Family in Mammary Tumorigenesis;128
7.5;V. Future Prospects;131
7.6;References;131
8;Chapter 5. Oncogenic Properties of the Middle T Antigens of Polyomaviruses;136
8.1;I. Introduction;136
8.2;II. Consequences of PymT Expression in Vivo;144
8.3;III. Expression of the Hamster Polyomavirus Middle T Arlcigen in Vivo;159
8.4;IV. Analysis of PyniT-Transformed Endothelial Cells;160
8.5;V. Outlook;164
8.6;References;165
9;Chapter 6. Selective Involvement of Protein Kinase C Isozymes in Differentiation and Neoplastic Transformation;170
9.1;I. Introduction;171
9.2;II. PKC Isoforms Involved in Differentiation;187
9.3;III. Involvement of PKC Isoforms in Tumorigenesis;198
9.4;IV. Conclusions;207
9.5;References;209
10;Chapter 7. Fc. Receptors in Malignancies: Friends or Enemies?;222
10.1;I. Introduction;222
10.2;II. Structural Features of Fc.Rs;223
10.3;III. Ligand Binding and Fc.R Binding Sites;226
10.4;IV. Functions Mediated by Membrane-Bound Fc.Rs;228
10.5;V. Signal Transduction Mediated by Fc.Rs;230
10.6;VI. Expression of Fc.Rs;232
10.7;VII. Soluble Fc. Receptors;236
10.8;VIII. Mechanisms of sFc.R (IgG-BF) Production;238
10.9;IX. Regulatory Role of Membrane-Bound and Soluble Fc.Rs;241
10.10;X. Expression of FcRs on Tumor Cells;244
10.11;XI. sFcRs in Malignancies;246
10.12;XII. Biological Role of FcR-Mediated Functions in Malignancies;247
10.13;XIII. Conclusions;248
10.14;References;249
11;Chapter 8. Dissecting Molecular Carcinogenesis: Development of Transgenic Mouse Models by Epidermal Gene Targeting;258
11.1;I. Introduction;258
11.2;II. Development of Single Transgenic Genotypes;261
11.3;III. Development of Multiple Transgenic Genotypes;285
11.4;IV. Development of a Rapid Screening System for Tumor Promoters and Chemical Carcinogenesis;297
11.5;V. Summary and Future Prospects;299
11.6;References;301
12;Index;308