Latchman Eukaryotic Transcription Factors

4. Auflage 2003
ISBN: 978-0-08-053126-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 384 Seiten, Web PDF

Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality. - Major families of eukaryotic transcription factors described - Mechanisms of gene activation and repression analysed - Structure-function relationships indicated - Interaction between transcription factors and chromatin structure described - Roles in inducible and cell type-specific gene expression - Roles in development, differentiation and human diseases including cancer - Methods of study in vitro and in vivo

Autoren/Hrsg.

Latchman, David S.

Inhaltsverzeichnis

1;Front Cover;1
2;Eukaryotic Transcription Factors;6
3;Copyright Page;7
4;Contents;8
5;List of Tables;14
6;About the author;16
7;Preface;18
8;Preface to the third edition;20
9;Preface to the second edition;22
10;Preface to the first edition;24
11;Acknowledgements;26
12;Chapter 1. DNA Sequences, Transcription Factors and Chromatin Structure;28
12.1;1.1 The importance of transcription;28
12.2;1.2 Chromatin structure and its remodelling;29
12.3;1.3 DNA sequence elements;34
12.4;1.4 Conclusions;46
13;Chapter 2. Methods for Studying Transcription Factors;50
13.1;2.1 Introduction;50
13.2;2.2 Methods for studying DNA–protein interactions;50
13.3;2.3 Methods for purifying and/or cloning transcription factors;61
13.4;2.4 Use of cloned genes;68
13.5;2.5 Conclusions;77
14;Chapter 3. RNA Polymerases and the Basal Transcriptional Complex;82
14.1;3.1 RNA polymerases;82
14.2;3.2 The stable transcriptional complex;84
14.3;3.3 RNA polymerase I;85
14.4;3.4 RNA polymerase III;87
14.5;3.5 RNA polymerase II;90
14.6;3.6 TBP, the universal transcription factor?;94
14.7;3.7 Conclusions;100
15;Chapter 4. Families of DNA Binding Transcription Factors;104
15.1;4.1 Introduction;104
15.2;4.2 The homeodomain;105
15.3;4.3 The two cysteine two histidine zinc finger;129
15.4;4.4 The multi-cysteine zinc finger;134
15.5;4.5 The basic DNA binding domain;144
15.6;4.6 Other DNA-binding motifs;151
15.7;4.7 Conclusions;152
16;Chapter 5. Activation of Gene Expression by Transcription Factors;162
16.1;5.1 Activation domains;162
16.2;5.2 Nature of activation domains;163
16.3;5.3 Interaction of activation domains with the basal transcriptional complex;169
16.4;5.4 Interaction of activation domains with other regulatory proteins;176
16.5;5.5 Other targets for transcriptional activators;189
16.6;5.6 Conclusions;201
17;Chapter 6. Repression of Gene Expression by Transcription Factors;210
17.1;6.1 Repression of transcription;210
17.2;6.2 Indirect repression;210
17.3;6.3 Direct repression;218
17.4;6.4 Other targets for transcriptional repressors;227
17.5;6.5 Conclusions;232
18;Chapter 7. Regulation of Transcription Factor Synthesis;238
18.1;7.1 Transcription factor regulation;238
18.2;7.2 Regulated synthesis of transcription factors;238
18.3;7.3 Mechanisms regulating the synthesis of transcription factors;256
18.4;7.4 Conclusions;267
19;Chapter 8. Regulation of Transcription Factor Activity;272
19.1;8.1 Evidence for the regulated activity of transcription factors;272
19.2;8.2 Regulation by protein–ligand binding;274
19.3;8.3 Regulation by protein–protein interactions;282
19.4;8.4 Regulation by protein modification;292
19.5;8.5 Regulation by protein degradation and processing;308
19.6;8.6 Role of regulated activity;310
19.7;8.7 Conclusions;312
20;Chapter 9. Transcription Factors and Human Disease;320
20.1;9.1 Diseases caused by transcription factor mutations;320
20.2;9.2 Cancer;324
20.3;9.3 Cellular oncogenes and cancer;326
20.4;9.4 Anti-oncogenes and cancer;341
20.5;9.5 Conclusions;358
21;Chapter 10. Conclusions and Future Prospects;368
22;Index;372
23;Color Plate Section;388