Leri / Anversa / Frishman Cardiovascular Regeneration and Stem Cell Therapy

1. Auflage 2008
ISBN: 978-0-470-99430-6
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 248 Seiten, E-Book

This book is the definitive reference on two of the most excitingareas of cardiovascular research - myocardial regenerationand stem cell therapy - for the treatment of disease. Editedby pioneers in the area, with contributions from every majorinvestigator worldwide, it covers:
* * The biology of stem cells
* The actions of stem cells from the bone marrow, the heart, andembryos on the normal restorative and repair functions of the heartand blood vessels
* How stem cells could contribute to myocardial recovery in theface of injury and aging
* How adjuvant therapy with growth factors might enhance stemcell activity in regeneration and repair
* Clinical applications and clinical experiences
This fully referenced publication presents the current state ofknowledge in both basic science and clinical practice, and is anessential reference for scientists, students, and clinicians.

Autoren/Hrsg.

Leri, Annarosa

Anversa, Piero

Frishman, William H.

Inhaltsverzeichnis

Contributors.
Preface.
Introduction.
Annarosa Leri, Piero Anversa, William Frishman.
Part I Stem Cell Biology.
1 Homing of Stem Cells and Tissue Injury.
Ayelet Dar, Orit Kollet, Tsvee Lapidot.
2 Adult Stem Cell Plasticity: Lineage potential on aContinuum.
Peter J. Quesenberry, Gerald Colvin, Mehrdad Abedi.
3 Embryonic Stem Cells and Cardiogenesis.
Timothy J. Kamp, Gary E. Lyons.
4 Mesenchymal Stem Cell-Derived Cardiomyogenic Cells.
Keiichi Fukuda, Jun Fujita, Daihiko Hakuno, ShinjiMakino.
5 Bone Marrow Cells and Vascular Growth.
Takayuki Asahara.
6 Progenitor Cells and Vascular Repair.
Kaushik Mandal, Marjan Jahangiri, Qingbo Xu.
Part II Cardiac Progenitor Cells in the Adult Heart.
7 Cardiac Side Population Cells: Phenotype and FunctionalSignificance.
Ronglih Liao, Frederic Mouquet, Otmar Pfister.
8 Phenotype and Function of c-kit Positive-Derived AmplifyingMyocytes.
Rachel Wilson, Xiongwen Chen, Hajime Kubo, Remus Berretta,Steven Houser.
9 Cardiac Stem Cells and their Niches.
Annarosa Leri, Alessandro Boni, Robert Siggins, AngeloNascimbene, Toru Hosoda.
10 Activation of the Local Regenerative System of the Heart.
Antonia Germani, Federica Limana, Maurizio C.Capogrossi.
Part III Progenitor Cells and the Diseased Heart.
11 Embryonic Stem Cells and Myocardial Regeneration.
Ahmad Y. Sheikh, Phillip C. Yang, Joseph C. Wu, Robert C.Robbins.
12 Bone Marrow-Derived Cells in Myocardial Repair andRegeneration.
Raj Kishore, Douglas W. Losordo.
13 Endothelial Progenitor Cells And The Infarcted Heart.
Stefanie Dimmeler, Masamichi Koyanagi, Carmen Urbich, AndreasM. Zeiher.
14 Cytokines and Heart Remodeling.
Issei Komuro, Hiroyuki Takano.
15 IGF-1, Muscle Progenitors and Heart Failure.
Nadia Rosenthal, Nadine Winn, Maria Paola Santini.
Part IV Cardiac Progenitor Cells and Heart Failure.
16 Cardiac Stem Cells and the Diabetic Cardiomyopathy.
Jan Kajstura, Nicole LeCapitaine, Maria Loredo, MarcoGiorgio, Thomas S. Mitchell, Susanna Valentini, Francesco Rotatori,Pier Giuseppe Pelicci.
17 Stem Cells and Cardiac Aging.
Roberto Bolli, Piero Anversa.
18 Bioengineered Scaffolds: Myocytes, Endothelial Cells andCardiac Repair.
Vincent F.M. Segers, Richard T. Lee.
19 Gene Therapy and Cellular Therapy in Cardiac Repair.
Mark A. Sussman.
20 Cardiac Stem Cells and the Failing Heart.
Piero Anversa, Konrad Urbanek, Claudia Bearzi, Antonella DeAngelis, Marcello Rota.
21 Myocardial Infarction: Risks and Hope.
Marc A. Pfeffer.
Part V Future Directions.
22 Conclusions - Future Directions.
Piero Anversa, Edmund H. Sonnenblick, WilliamFrishman.
Index

Über Autor(innen)

Annarosa Leri MD is a lead investigator in theCardiovascular Research Institute at the New York Medical Collegewhere this field of investigation began. She has made majorcontributions to our understanding of the basic mechanisms involvedin stem cell regenerative therapy for the cardiovascular system.Dr. Leri is Professor of Medicine of the Cardiovascular ResearchInstitute of the New York Medical College in Valhalla, New York.She is co-editor and author.
Piero Anversa MD Dr. Anversa is Director of theCardiovascular Research Institute at New York Medical College, andis the founder of the field of stem cell therapy and regenerativecardiovascular medicine. In recognition of his contributions, Dr.Anversa received the 2004 Distinguished Scientist Award of theAmerican Heart Association.
Professor William H Frishman MD is one of the leadingcardiovascular investigators in the world, with emphasis in thearea of cardiovascular therapeutics. He is author, co-author,editor and co-editor of 12 textbooks and 800 original articles andchapters. He is currently supplements editor of the AmericanJournal of Medicine, co-editor of the Year Book ofMedicine and co-editor-in-chief of the journal Cardiology inReview. Dr. Frishman is the Rosenthal Professor and Chairman ofthe Department of Medicine at New York Medical College in Valhalla,New York. He is co-editor and co-author.