Levitan / Barrantes Cholesterol Regulation of Ion Channels and Receptors

1. Auflage 2012
ISBN: 978-1-118-34228-2
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 302 Seiten, E-Book

Examines new research on the role of cholesterol inregulating ion channels and receptors and its effect onhealth
Drawing together and analyzing all the latest research findings,this book explores the role of cholesterol in the regulation of ionchannels and receptors, including its pathological effects. It isthe first book to comprehensively describe the complex mechanismsby which cholesterol regulates two major classes of membraneproteins. Moreover, it sheds new light on how cholesterol affectsessential cellular functions such as the contraction of the heart,propagation of nerve impulses, and regulation of blood pressure andkidney function.
Written and edited by leading pioneers in the field,Cholesterol Regulation of Ion Channels and Receptors isdivided into three parts:
* Part I, Cholesterol Regulation of Membrane Properties,introduces the heterogeneity of cholesterol distribution inbiological membranes and the physical and biological implicationsof the formation of cholesterol-rich membrane domains.
* Part II, Cholesterol Regulation of Ion Channels,examines the mechanisms underlying cholesterol sensitivities of ionchannels, including the regulation of ion channels by cholesterolas a boundary lipid.
* Part III, Cholesterol Regulation of Receptors, exploresthe latest discoveries concerning how cholesterol regulatesdistinct types of receptors, including G-protein coupled receptors,LDL and scavenger receptors, and innate immune systemreceptors.
Increased levels of cholesterol represent a major health risk.Understanding cholesterol regulation of ion channels and receptorsis essential for facilitating the development of new therapeuticstrategies to alleviate the impact of pathological cholesterolconditions. With this book as their guide, readers have access tothe most current knowledge in the field.

Autoren/Hrsg.

Levitan, Irena

Barrantes, Francisco

Inhaltsverzeichnis

FOREWORD vii
PREFACE ix
CONTRIBUTORS xi
I CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES 1
1 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULARMEMBRANES 3
Daniel Wu¨ stner, Lukasz Michael Solanko, and Frederik W.Lund
2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGESIN BILAYER PHYSICAL PROPERTIES--AN ENERGETIC PERSPECTIVE27
Jens A. Lundbæk and Olaf S. Andersen
II CHOLESTEROL REGULATION OF ION CHANNELS 45
3 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROLSENSITIVITY OF KIR CHANNELS 47
Avia Rosenhouse-Dantsker and Irena Levitan
4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+CHANNELS 69
Hwei L. Ong and Indu S. Ambudkar
5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS 91
Elise Balse, Ste´ phane Hatem, and Stanley Nattel
6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMICREGULATION OF CHANNEL FUNCTION BY STEROIDS 109
Alex M. Dopico, Anna N. Bukiya, and Aditya K. Singh
7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINSIN THE IMMUNE SYSTEM 135
Nu´ ria Comes and Antonio Felipe
8 INDIRECT CHANNEL REGULATION BY CHOLESTEROL: THE ROLE OFCAVEOLAE AND CAVEOLINS IN REGULATING KATP CHANNEL FUNCTION161
Caroline Dart
III CHOLESTEROL REGULATION OF RECEPTORS 181
9 REGULATION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR BYCHOLESTEROL AS A BOUNDARY LIPID 183
Francisco J. Barrantes
10 SPECIFIC AND NONSPECIFIC REGULATION OF GPCR FUNCTION BYCHOLESTEROL 205
Gerald Gimpl and Katja Gehrig-Burger
11 STRUCTURAL INSIGHTS INTO CHOLESTEROL INTERACTIONS WITHG-PROTEIN-COUPLED RECEPTORS 231
Jeremiah S. Joseph, Enrique E. Abola, and Vadim Cherezov
12 MEMBRANE CHOLESTEROL: IMPLICATIONS IN RECEPTOR FUNCTION255
Sandeep Shrivastava and Amitabha Chattopadhyay
13 THE ROLE OF CHOLESTEROL AND LIPID RAFTS IN REGULATION OF TLRRECEPTORS 273
Ruxana T. Sadikot
INDEX 281

Über Autor(innen)

IRENA LEVITAN, PhD, is Associate Professor of Medicine atthe University of Illinois College of Medicine at Chicago. Herresearch interests focus on the impact of dyslipidemia on K+channels and endothelial biomechanics.
FRANCISCO J. BARRANTES is the former head of the NationalResearch Council (CONICET) - Bahia Blanca and UNESCO Chair ofBiophysics and Molecular Neurobiology. Currently, he is Director ofthe Laboratory of Molecular Neurobiology and Professor at theFaculty of Medical Sciences, Pontifical Catholic University ofArgentina. His current research interests focus on theunderstanding of nicotinic acetylcholine receptor-membranecross-talk.