Moldave Progress in Nucleic Acid Research and Molecular Biology

1. Auflage 2000
ISBN: 978-0-08-052264-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 66, 394 Seiten, Web PDF

Reihe: Progress in Nucleic Acid Research and Molecular Biology

Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. - Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology - Features contributions from leaders in their fields - Contains abundant references

Autoren/Hrsg.

Moldave, Kivie

Inhaltsverzeichnis

1;Cover;1
2;Title page;4
3;Copyright Page;5
4;Contents;6
5;Some Articles Planned for Future Volumes;10
6;Chapter 1. Structure, Mechanism, and Evolution of the mRNA Capping Apparatus ;12
6.1;I. Genetic and Physical Organization of the Cellular Capping Apparatus;14
6.2;II. Structure and Mechanism of mRNA Guanylyltransferase ;15
6.3;III. Structure and Mechanism of Yeast RNA Triphosphatase;23
6.4;IV. Metazoan RNA Triphosphatase;30
6.5;V. Assembly of the Yeast Triphosphatase–Guanylyltransferase Complex ;33
6.6;VI. Other RNA Triphosphatases of Unknown Function;35
6.7;VII. Cap Methyltransferase;39
6.8;VIII. Perspective;45
6.9;References;46
7;Chapter 2. Folding of a Nascent Peptide on the Ribosome;52
7.1;I. Introduction;53
7.2;II. RNA Binding Sites during Translation;54
7.3;III. Ribosomal RNA and Peptide Synthesis;56
7.4;IV. Nascent Peptides;58
7.5;V. Tunnel in the Large Ribosomal Subunit.;62
7.6;VI. Folding of Nascent Peptides;65
7.7;VII. Pause-Site Peptides;66
7.8;VIII. Chaperonelike Activity of Ribosomes;67
7.9;IX. Effects of Chaperones on Nascent Peptides;68
7.10;X. Problems and Prospects;71
7.11;References;73
8;Chapter 3. Exoribonucleases and Their Multiple Roles in RNA Metabolism ;78
8.1;I. Overview of Exoribonuclease Diversity and Function;79
8.2;II. Catalog of Exoribonucleases.;82
8.3;III. Exoribonucleases in Multienzyme Complexes;102
8.4;IV. Concluding Remarks;105
8.5;References;106
9;Chapter 4. Protein Traffic in Bacteria: Multiple Routes From the Ribosome To and Across the Membrane ;118
9.1;I. SecA/SecB-Dependent Targeting to the SecYE Translocon;120
9.2;II. SRP-Dependent Targeting to the SecYE Translocon;126
9.3;III. Is There a Concerted Targeting by SRP and SecA/SecB to the SecYE Translocon? ;134
9.4;IV. Translocation and Integration at the SecYE Translocon;135
9.5;V. Spontaneous Insertion into the Plasma Membrane;142
9.6;VI. TAT-Specific Targeting and Export;147
9.7;VII. Posttranslocational Events in the Periplasmic Space;149
9.8;References;152
10;Chapter 5. The Intrinsically Unstable Life of DNA Triplet Repeats Associated with Human Hereditary Disorders ;170
10.1;I. Diseases Associated with Expansions of DNA Triplet Repeats.;171
10.2;II. Mechanisms of Disease Pathology Caused by Expansions of DNA Triplet Repeats ;176
10.3;III. Molecular Mechanisms of Expansions and Deletions of DNA-Triplet Repeats ;180
10.4;IV. Genetic Instabilities of Other Microsatellite Sequences;200
10.5;V. Summary and Future Prospects;201
10.6;References;203
11;Chapter 6. Molecular and Cell Biology of Acid B-Glucosidase and Prosaposin ;214
11.1;I. Molecular and Cell Biology of Acid B-Glucosidase;215
11.2;II. Molecular Biology and Function of Prosaposin and Saposins;222
11.3;III. Multifunctional Roles of Saposin C and Prosaposin;232
11.4;IV. Conclusions.;245
11.5;References;246
12;Chapter 7. Regulation and Function of the Cyclic Nucleotide Phosphodiesterase (PDE3) Gene Family ;252
12.1;I. Introduction;253
12.2;II. The PDE3 Gene Family;258
12.3;III. Hormonal Regulation of PDE3 Enzymes;265
12.4;IV. Long-Term Regulation of PDE3 Enzymes;271
12.5;V. Pharmacology and Potential Therapeutic Applications of PDE3 Inhibitors;273
12.6;VI. Present and Future Therapeutic Applications for PDE3 Inhibitors;279
12.7;References;281
13;Chapter 8. Understanding Nuclear Receptor Function: From DNA to Chromatin to the Interphase Nucleus ;290
13.1;I. Identification of Regulatory Elements for Steroid Receptors;290
13.2;II. Chromatin Involvement in Gene Regulation by Steroid Receptors;292
13.3;III. Beyond the Chromatin Fiber: Receptor Traf.cking in Living Cells;307
13.4;References;312
14;Chapter 9. A Unique Combination of Transcription Factors Controls Differentiation of Thyroid Cells ;318
14.1;I. Introduction;319
14.2;II. Expression, Biological Effects, and Molecular Characteristics of the Thyroid-Specific Transcription Factors ;323
14.3;III. Target Genes, Cooperativity, Recycling, and Regulation;341
14.4;IV. Thyroid-Speci.c Transcription Factors in Congenital Hypothyroidism;350
14.5;V. Conclusions and Perspectives;352
14.6;References;354
15;Chapter 10. Regulation of Metallothionein Gene Expression;368
15.1;I. Metallothionein Proteins;369
15.2;II. Probable Functions of Metallothioneins;370
15.3;III. Gene Structure of Mammalian Metallothioneins;372
15.4;IV. CIS-Acting Elements in MT-I Promoter;373
15.5;V. Trans-Acting Factors;373
15.6;VI. Basal Expression;373
15.7;VII. Heavy Metal–Induced Expression;376
15.8;VIII. Induction by Other Agents;378
15.9;IX. Tissue-Speci.c Expression;381
15.10;X. Role of Repressors;382
15.11;XI. Role of Chromatin Structure;383
15.12;XII. Regulation by Epigenetic Mechanism;384
15.13;XIII. Concluding Remarks;389
15.14;References;390
16;Index;396