Murre Long Range Regulation of V(D)J Recombination

1. Auflage 2015
ISBN: 978-0-12-803330-2
Verlag: Academic Press
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band 128, 454 Seiten, Format (B × H): 152 mm x 229 mm

Reihe: Advances in Immunology

Long Range Regulation of V(D)J Recombination, the latest volume in the Advances in Immunology series focuses on the generation of an effective immune response to invading pathogens

As B and T lymphocytes are characterized by the expression of antigen receptors that specifically recognize determinants expressed on pathogens, this volume discusses how antigen receptors are synthesized in B and T lymphocytes.



- Focuses on the generation of an effective immune response to invading pathogens
- Contains contributions from leading authorities
- Informs and updates on all the latest developments in the field of immunology

Autoren/Hrsg.

Murre, Cornelis

Weitere Mitwirkende

Murre, Cornelis

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Infektionskrankheiten
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

- Regulation and Evolution of the RAG Recombinase
Grace Teng and David G. Schatz
- Chromatin Interactions in the Control of Immunoglobulin Heavy Chain Gene Assembly
Gita Kumari and Ranjan Sen
- Spatial Regulation of V-(D)J Recombination at Antigen Receptor Loci
Anja Ebert, Louisa Hill and Meinrad Busslinger
- Long Range Regulation of V(D)J Recombination
Charlotte Proudhon, Bingtao Hao, Ramya Raviram, Julie Chaumeil and Jane A. Skok
- Dynamic Control of Long-range Genomic Interactions at the Immunoglobulin ? Light Chain Locus
Claudia Ribeiro de Almeida, Rudi W. Hendriks and Ralph Stadhouders
- Regulation of Tcrb Gene Assembly by Genetic, Epigenetic, and Topological Mechanisms
Kinjal Majumder, Craig H. Bassing and Eugene M. Oltz
- Chromatin Dynamics and the Development of the TCR? and TCRd  Repertoires
Zachary Carico and Michael S. Krangel
- Long-range Control of V(D)J Recombination & Allelic Exclusion: Modeling Views
Pernelle Outters, Sébastien Jaeger, Nancy Zaarour and Pierre Ferrier

Über Autor(innen)

Murre, Cornelis
Cornelis Murre performed his graduate work as a joined program with the University of Leiden at Harvard Medical School. He was a postdoctoral fellow at the Whitehead Institute. He is a Searle Scholar and the recipient of the National Institutes of Health Merit Award. Currently he is a Distinguished Professor in the Biological Sciences at the University of California, San Diego.

Dr. Murre has focused his research on the regulation and function of helix-loop-helix (HLH) proteins in stem cells, lymphocyte development and homeostasis. Control of tissue-specific gene expression during B and T lymphocyte development, cell growth, cell death and aging are the prominent themes in his research. Specifically the Murre laboratory has shown that subset of HLH proteins, the "E proteins", contribute to B lineage- and T lineage- specific gene expression programs, regulate lymphocyte survival and cellular proliferation, activate the rearrangement of antigen receptor genes, and control progression through critical developmental checkpoints. In more recent studies they have constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate. Currently, his studies are focused on physical mechanisms that underpin the generation of antigen receptor diversity.