Primrose / Twyman Genomics

Applications in Human Biology
1. Auflage 2008
ISBN: 978-0-470-75127-5
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 232 Seiten, E-Book

Written by the successful author team of Sandy Primrose and RichardTwyman, Genomics: Applications in Human Biology is a topicalbook showing how the new science of genomics is adding impetus tothe advances in human health provided by biotechnology.
* * Written to provide the necessary overview of the subject,covering technological developments, applications and (wherenecessary) the ethical implications.
* Divided into three sections, the first section introduces therole of biotechnology and genomics in medicine and sets out some ofthe technological advances that have been the basis of recentmedical breakthroughs.
* The second section takes a closer look at how biotechnology andgenomics are influencing the prevention and treatment of differentcategories of disease.
* Finally the contribution of biotechnology and genomics to thedevelopment of different types of therapy is described, includingconventional drugs, recombinant proteins and gene/celltherapies.
* References to appropriate sections in other two popular books,authored by Sandy Primrose and Richard Twyman, are included -Principles of Gene Manipulation and Principles of Gene Analysis andGenomics.
* Features several categories of boxed text, including historyboxes (describing the origins and development of particulartechnologies or treatments), molecular boxes (featuring themolecular basis of diseases or treatments in more detail) and ethicboxes (which discusses the ethical implications of technologydevelopment and new therapies).

Autoren/Hrsg.

Primrose, Sandy B.

Twyman, Richard

Inhaltsverzeichnis

Chapter One: Biotechnology And Genomics In Medicine.
Introduction.
Recombinant DNA Technology.
From Recombinant DNA To Molecular Medicine.
Gene Medicine.
Disease Models.
The Impact Of Genomics On Medicine.
The New Molecular Medicine.
Outline Of This Book.
Further Reading.
Chapter Two: An Overview Of Genomics.
Introduction.
A Review Of Progress: The Human Genome Project.
The Future: Functional Genomics.
Mutational Genomics.
Further Reading.
Chapter Three: Genomics And The Challenge Of InfectiousDisease.
Microorganisms Causing Disease.
Where Do New Diseases Come From?.
Identifying The Causative Agent Of A Disease.
Molecular Epidemiology.
Host Resistance To Infection.
Understanding Bacterial Pathogenicity.
Comparative Genomics And Genome Plasticity.
Combating Infectious Disease.
Further Reading.
Chapter Four: Analyzing And Treating GeneticDiseases.
Genetic Disease In Context.
Detecting Single Gene Disorders.
Treating Single Gene Disorders.
Finding Genes For Monogenic Diseases And Determining GeneFunction.
Analysis Of Polygenic Disorders.
Haplotypes.
The Major Histocompatibility Complex (MHC).
Individual Responses To Drugs (Pharmacogenomics).
Further Reading.
Chapter Five: Diagnosis And Treatment Of Cancer.
Introduction.
The Impact Of Genomics On Cancer Research.
New Methods For The Diagnosis Of Cancer.
New Approaches To Cancer Therapy.
Further Reading.
Chapter Six: The Large Scale Production OfBiopharmaceuticals.
Overview.
The Generation Of Monoclonal Antibodies.
The Large Scale Culture Of Microorganisms.
The Large Scale Culture Of Animal Cells.
Expression Systems.
Downstream Processing.
Using Gene Manipulation To Facilitate Downstream Processing. OfBiopharmaceuticals.
The Quality Of Biopharmaceuticals.
Good Manufacturing Practice.
Alternative Production Systems.
Further Reading.
Chapter Seven: Genomics And The Development Of New ChemicalEntities.
Introduction. How Drugs Are Developed.
High-Throughput Screening.
Target Validation And Animal Models.
Combinatorial Chemistry.
Dynamic Combinatorial Libraries.
Virtual Screening.
Combinatorial Biosynthesis And Chemobiosynthesis.
Drug Metabolism.
Toxicogenomics.
Further Reading.
Chapter Eight: Gene And Cell Therapies.
Introduction.
Gene Therapy.
Nucleic Acids As Drugs.
DNA Vaccines.
Disease Models.
Cell Therapy.
Further Reading.

Über Autor(innen)

Sandy Primrose was an academic for 10 years and a seniormanager in the biotechnology industry for 20 years. He now managesa consultancy practice focused on technology management. He is alsoVisiting Professor at the Universities of Warwick and Liverpool,and sits on the board of a number of biotechnology companies.
Richard Twyman worked as a research scientist at theUniversity of Warwick and the MRC Laboratory of Molecular Biologyin Cambridge before taking up scientific writing as a full-timeoccupation in 1998. He is currently a Visiting Fellow at theDepartment of Biology, University of York, and manages a companythat provides scientific writing services.