Ramamoorthy NMR Spectroscopy of Biological Solids

Erscheinungsjahr 2010
ISBN: 978-1-4200-2761-7
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 368 Seiten

Reihe: Practical Spectroscopy

Over the past decade, a myriad of techniques have shown that solid-state nuclear magnetic resonance (NMR) can be used in a broad spectrum of applications with exceptionally impressive results. Solid-state NMR results can yield high-resolution details on the structure and function of many important biological solids, including viruses, fibril-forming molecules, and molecules embedded in the cell membrane. Filling a void in the current literature, NMR Spectroscopy of Biological Solids examines all the recent developments, implementation, and interpretation of solid-state NMR experiments and the advantages of applying them to biological systems. The book emphasizes how these techniques can be used to realize the structure of non-crystalline systems of any size. It explains how these isotropic and anisotropic couplings interactions are used to determine atomic-level structures of biological molecules in a non-soluble state and extrapolate the three-dimensional structure of membrane proteins using magic-angle spinning (MAS). The book also focuses on the use of multidimensional solid-state NMR methods in the study of aligned systems to provide basic information about the mechanisms of action of a variety of biologically active molecules. Addressing principles, methods, and applications, this book provides a critical selection of solid-state NMR methods for solving a wide range of practical problems that arise in both academic and industrial research of biomolecules in the solid state. NMR Spectroscopy of Biological Solids is a forward-thinking resource for students and researchers in analytical chemistry, bioengineering, material sciences, and structural genomics.

Zielgruppe

Industrial and academic researchers in chemistry, pharmacology, biology, and biophysics; graduate students in biology, chemistry, and biophysics, as well as medicine and pharmacology

Autoren/Hrsg.

Ramamoorthy, A.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

Magic-Angle Spinning Recoupling Techniques for Distance Determinations among Spin-1/2 Nuclei in Solid Peptides and Proteins; C.M. Rienstra
Spectral Assignment of (Membrane) Proteins Under Magic-Angle Spinning; M. Baldus
Resonance Assignments and Secondary Structure Determination in Uniformly and Differentially Enriched Proteins and Protein Reassemblies by Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy; T. Polenova
Torsion Angle Determination in Biological Solids by Solid-State Nuclear Magnetic Resonance; M. Hong and S. Wi
Structural Studies of Peptides on Biomaterial Surfaces Using Double-Quantum Solid-State Nuclear Magnetic Resonance Spectroscopy; G.P. Drobny, P.S. Stayton, J.R. Long, E. Louie, T. Karlsson, J.M. Popham, N.A. Oyler, P.V. Bower, and W.J. Shaw
Sensitivity Enhancement by Inverse Detection in Solids; K. Saalwachter and A. Ramamoorthy
Uniaxial Motional Averaging of the Chemical Shift Anisotropy of Membrane Proteins in Bilayer Environments; A.A. Nevzorov, A.A. De Angelis, Sang Ho. H. Park, and S.J. Opella
Nuclear Magnetic Resonance Structural Studies of the FXYD Family Membrane Proteins in Lipid Bilayers; C.M. Franzin, J. Yu, and F.M. Marassi
Solid-State 19F-Nuclear Magnetic Resonance Analysis of Membrane-Active Peptides; A.S. Ulrich, P. Wadhwani, Ulrich H.N. Dürr, S. Afonin, R.W. Glaser, E. Strandberg, P. Tremouilhac, C. Sachse, M. Berditchevskaia, and S. Grage
Solid-State Nuclear Magnetic Resonance Spectroscopic Studies of Magnetically Aligned Phospholipid Bilayers; G.A. Lorigan
Computational Aspects of Biological Solid-State Nuclear Magnetic Resonance Spectroscopy; N.C. Nielsen
Chemical Shift Tensors of Nucleic Acids: Theory and Experiment; J. Persons, P. Rossi, and G.S. Harbison
Solid-State Nuclear Magnetic Resonance Studies of Alkali Metal Ions in Nucleic Acids and Related Systems; G. Wu and A. Wong Index