Rios / Escarpa / Simonet Miniaturization of Analytical Systems

Principles, Designs and Applications
1. Auflage 2009
ISBN: 978-0-470-74810-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 384 Seiten, E-Book

The book describes a general vision of the miniaturization of the analytical systems, including their principles, designs and applications. Through ten chapters the different aspects characterizing the miniaturized systems are developed. Thus, the two first chapters include the basic concepts behind miniaturization in analytical chemistry, as well as the mechanical and electronic tools needed for designing and fabricating miniaturized analytical systems. Chapters 3 to 6 represent the core of the book, as they take as the basis the analytical process and deal with the miniaturization of sample treatment (including the consequent automation), with sections devoted to the problems associated with sample introduction in micro(nano) systems; miniaturized systems for analyte separation, depending of the forces involved in moving the flow; and detection in micro-size environments. Following on, Chapters 7 and 8 will deal with the miniaturization of the entire process: from sample introduction to the generation of the corresponding analytical results. The last part of the book will deal with two aspects of miniaturized analytical systems directly connected to their usefulness: the design of portable miniaturized systems (interesting for performing field tests) and how to assure the practical reliability of the micro(nano) systems (quality control tests, performance and validation activities, as well as the robustness of the miniaturized depicted systems. The ruggedness of micro(nano) systems are briefly discussed and related to the tools for designing and fabricating described in the first chapters of the book.

Autoren/Hrsg.

Rios, Angel

Escarpa, Alberto

Simonet, Bartolome

Inhaltsverzeichnis

Preface.
1 Miniaturization in Analytical Chemistry.
1.1 Introduction.
1.2 Miniaturization as One of the Critical Trends in ModernAnalytical Chemistry.
1.3 Evolution in the Field of Analytical Miniaturization.
1.4 Classification of Miniaturized Analytical Systems andDefinition of Terms.
1.5 Theory of Miniaturization.
1.6 Features of Miniaturized Analytical Systems.
1.7 Incidences of Miniaturization in the Analytical Process.
1.8 Outlook.
References.
2 Tools for the Design of Miniaturized AnalyticalSystems.
2.1 Introduction.
2.2 Miniaturized Analytical Processes: The Downsizing andIntegrating Phenomena.
2.3 Microfluidic Devices.
2.4 Microtechnology.
2.5 MEMS and NEMS.
2.6 Outlook.
References.
3 Automation and Miniaturization of Sample Treatment.
3.1 Introduction.
3.2 Simplification of Sample Treatment: MicroextractionTechniques.
3.3 Simplification of Sample Treatment: Continuous FlowSystems.
References.
4 Miniaturized Systems for Analytical Separations I: SystemsBased on a Hydrodynamic Flow.
4.1 Introduction.
4.2 The Earliest Example of Miniaturization of a GasChromatograph and Some Other Developments.
4.3 Capillary Liquid Chromatography (CLC).
4.4 Liquid Chromatography on Microchips.
References.
5 Miniaturized Systems for Analytical Separations II: SystemsBased on Electroosmotic Flow (EOF).
5.1 Introduction.
5.2 CE on the Microchip Format.
5.3 Modes and Theories of CE Microchips.
5.4 Microfabrication Techniques.
5.5 Basic Fluidic Manipulation/Motivation: ElectrokineticInjection and Separation Protocols.
5.6 Electrochromatography in Microchip Format: Designs andApplications.
5.7 Comparison of Hydrodynamic and Electroosmotic Flow-drivenMiniaturized Systems.
5.8 Analytical Applications.
5.9 Outlook.
References.
6 Detection in Miniaturized Analytical Systems.
6.1 Introduction.
6.2 Laser-induced Fluorescence (LIF) Detection.
6.3 Electrochemical Detection (ED).
6.4 Microfluidics-MS Interfacing.
6.5 Unconventional Detection Methods.
6.6 Outlook.
References.
7 Miniaturization of the Entire Analytical Process I:Micro(nano)sensors.
7.1 Introduction.
7.2 Evolution of Sensors with Nanotechnology.
7.3 Micro(nano)sensors.
7.4 Nanoprobes for In Vivo Bioanalysis.
References.
8 Miniaturization of the Entire Analytical Process II: MicroTotal Analysis Systems (muTAS).
8.1muTAS, Microfluidics and Lab-on-a-Chip: Conceptsand Terminology.
8.2 Basic Concepts of Microfluidics: The Design of AnalyticalMicrosystems.
8.3 The Basics of Downscaling in Microsystems.
8.4 Microfluidic Platforms: Types, Principles andClassification.
8.5 Microfluidic Devices for Analytical Lab-on-a-ChipApplications.
8.6 Outlook.
References.
9 Portability of Miniaturized Analytical Systems.
9.1 Introduction.
9.2 Portable Gas Analysers.
9.3 Portable Electrochemical Analysers.
9.4 Portable Optical Analysers.
9.5 Portable Lab-on-a-Chip Analysers.
References.
10 Analytical Performance of Miniaturized AnalyticalSystems.
10.1 Introduction.
10.2 Quality Control in Miniaturized Systems.
10.3 Validation of Microsystems.
10.4 Qualification of Microsystems.
10.5 Robustness of Microsystems.
Further Reading.
Index.