Schardein / Macina Human Developmental Toxicants

Aspects of Toxicology and Chemistry
Erscheinungsjahr 2006
ISBN: 978-1-4200-0675-9
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 427 Seiten

Presenting the first database of its kind, this unique reference illustrates the relationships between the chemistry and developmental toxicity of a number of important pharmaceuticals and industrial toxicants. Human Developmental Toxicants contains up-to-date and concise information on the chemical structures, properties, and biological activities for 50 known agents that adversely affect prenatal and postnatal human development in terms of growth, viability, structure, and function.

This book presents data linking chemical and structural properties of specific toxicants as they relate to toxic effects, dosage, timing, and route of exposure. Focusing on one compound per chapter, the book also includes associated biological data from animals for each agent covered. An accompanying CD summarizes all of the data discussed in the text within an electronic database. In addition, the CD contains three-dimensional structure representations and 49 calculated physicochemical and topological parameters of the selected molecules. This information is useful for building structure activity relationship (SAR) models linking the chemical properties with observed human developmental toxicity.

As scientists continue to explore how chemicals alter human development, Human Developmental Toxicants contains the necessary information to further identify which chemical properties are responsible for adverse effects. This reference provides toxicologists, teratologists, chemists and other scientists with the latest data and information needed to perform risk assessments, predict chemicals that may produce developmental toxicity, and regulate harmful exposure.

Zielgruppe

Toxicologists, teratologists, chemists, and other scientists interested in human and mammalian development.

Autoren/Hrsg.

Schardein, James L.

Macina, Orest T.

Fachgebiete

• Naturwissenschaften Biowissenschaften Toxikologie
• Naturwissenschaften Biowissenschaften Entwicklungsbiologie

Inhaltsverzeichnis

Each chapter is dedicated to a single compound and provides a general introduction followed by a description of that compound's developmental toxicology in animals and humans, a detailed analysis of its chemistry and calculated physicochemical properties, and references.

Aminopterin
Busulfan
Cyclophosphamide
Methotrexate
Chlorambucil
Mechlorethamine
Cytarabine
Tretinoin
Propranolol
Penicillamine
Vitamin A
Carbamazepine
Danazol
Paramethadione
Carbon Monoxide
Formaldehyde
Isotretinoin
Captopril
Misoprostol
Streptomycin
Methimazole
Ethylene Oxide
Tetracycline
Caffeine
Thalidomide
Primidone
Fluconazole
Ergotamine
Propylthiouracil
Medroxyprogesterone
Cocaine
Quinine
Methylene Blue
Warfarin
Phenobarbital
Trimethoprim
Methyltestosterone
Disulfiram
Valproic Acid
Carbon Disulfide
Norethindrone
Phenytoin
Etretinate
Toluene
Ethisterone
Acitretin
Valsartan
Diethylstilbestrol
Pseudoephedrine
Ethanol
Discussion and Summary
Appendix I: Physicochemical Parameter Histograms
Appendix II: Topological Parameter Histograms
Appendix III: Description of of Accompanying CD
Index