E-Book, Englisch, 510 Seiten, Web PDF
Schröder / Lübke The Peptides
1. Auflage 2014
ISBN: 978-1-4832-6172-0
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark
Methods of Peptide Synthesis
E-Book, Englisch, 510 Seiten, Web PDF
ISBN: 978-1-4832-6172-0
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark
The Peptides, Volume I: Methods of Peptide Synthesis focuses on detailed description of protecting groups, individual amino acids, and coupling reactions. The publication first offers information on amino-protecting and carboxyl-protecting groups, including carboxyl protection by salt formation, esterification, and amide formation and acyl-type, alkyl-type, and urethane protecting groups. The text then examines the formation of the peptide bond and amino acids. Discussions focus on amino acids with the alcoholic hydroxyl group, sulfur amino acids, basic and acidic amino acids, synthesis of peptides by activation of the amino group, and peptide synthesis by activation of the carboxyl group. The manuscript elaborates on the synthesis of cyclic peptides, depsipeptides, peptoids, and the plastein reaction. Topics include synthesis of plastein-active peptides, glycopeptides, phosphopeptides, and S-peptides. The publication is a dependable source of data for readers interested in the methods of peptide synthesis.
Autoren/Hrsg.
Weitere Infos & Material
1;Front Cover;1
2;Methods of Peptide Synthesis;4
3;Copyright Page;5
4;Table of Contents;10
5;PREFACE;6
6;Contents of Volume II;12
7;Nomenclature of Amino Acids and Peptides;14
8;INTRODUCTION;32
9;CHAPTER I. AMINO-PROTECTING GROUPS;34
9.1;A. Acyl-Type Protecting Groups;34
9.2;B. Urethan Protecting Groups;53
9.3;C. Alkyl-Type Protecting Groups;75
9.4;D. Arylidene-Type Protecting Groups;80
9.5;E. Protection by Protonation;81
10;CHAPTER II. CARBOXYL-PROTECTING GROUPS;83
10.1;A. Carboxyl Protection by Esterification;83
10.2;B. Carboxyl Protection by Hydrazide or Amide Formation;95
10.3;C. Carboxyl Protection by Salt Formation;100
11;CHAPTER III. FORMATION OF THE PEPTIDE BOND;107
11.1;A. Classical Methods;107
11.2;B. Peptide Synthesis by Activation of the Carboxyl Group;108
11.3;C. Synthesis of Peptides by Activation of the Amino Group;159
12;CHAPTER IV. AMINO ACIDS;168
12.1;A. Monoaminomonocarboxylic Acids;168
12.2;B. Basic Amino Acids;181
12.3;C. Acidic Amino Acids;212
12.4;D. Diaminodicarboxylic Acids;238
12.5;E. Amino Acids with the Alcoholic Hydroxyl Group;238
12.6;F. Amino Acids with the Aromatic Hydroxyl Group;251
12.7;G. Sulfur Amino Acids;257
13;CHAPTER V. THE SYNTHESIS OF CYCLIC PEPTIDES;302
13.1;A. Homodetic Cyclic Peptides;302
13.2;B. Heterodetic Cyclic Peptides;306
14;CHAPTER VI. DEPSIPEPTIDES;318
14.1;A. O-Peptides;318
14.2;B. S-Peptides;319
14.3;C. Peptolides;320
15;CHAPTER VII. PEPTOIDS;325
15.1;A. Phosphopeptides;325
15.2;B. Glycopeptides;330
15.3;C. Nucleopeptides;336
15.4;D. Chromopeptides;339
16;CHAPTER VIII. THE PLASTEIN REACTION;343
16.1;A. Plastein Formation of Natural Peptides;343
16.2;B. Synthesis of Plastein-Active Peptides;344
17;CHAPTER IX. SOLID PHASE PEPTIDE SYNTHESIS;348
18;CHAPTER X. PROBLEMS OF RACEMIZATION;350
18.1;A. Methods for the Determination of Racemization;350
18.2;B. Theory of Racemization;354
18.3;C. Tendency to Racemization of the Most Important Coupling Methods;356
19;BIBLIOGRAPHY;358
20;AUTHOR INDEX;444
21;SUBJECT INDEX;494
