Therman / Susman Human Chromosomes

Structure, Behavior, and Effects
Third Auflage 1993
ISBN: 978-1-4684-0529-3
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Web PDF

Reihe: Springer Study Edition

This book, like the two previous editions, was written as an introduction to human cytogenetics, but it could also be used as a text for a general cytogenetics course, since chromosome structure and behavior are similar in all eukaryotes. Many examples in this book are from organisms other than humans, reflecting our combined backgrounds of molecular and bacterial genetics, and plant and animal cytogenetics. In the rapidly expanding field of human cytogenetics, certain subjects, for instance clinical and cancer cytogenetics, are now covered in recently published, thousand-page volumes. In this book, such subjects are presented only in outline. The enormous growth of information has also made the choice of topics and of examples to illustrate them even more arbitrary and subjective than in the previous editions. Apart from a few pages here and there, the text has been rewritten. Major parts, especially those on molecular matters, have been added. This book would not exist without the dedicated participation of Mrs. Barbara Susman. She has been involved in the project from the planning stages to the final proofreading. She has done the extensive literature research, designed most of the tables and illustrations, and edited and typed the text. For discussions and suggestions we are indebted to many colleagues. We wish especially to mention Drs. Lassi Alvesalo, Evelyn M. Kuhn, and Renata Laxova, who have critically read selected parts of the book, and Dr. Carter Denniston, who has read the whole text.

Zielgruppe

Graduate

Autoren/Hrsg.

Therman, Eeva

Susman, Millard

Inhaltsverzeichnis

1. Origins and Directions of Human Cytogenetics.- 2. Structure of the Eukaryotic Chromosome and the Karyotype.- 3. Mitotic Cycle and Chromosome Reproduction.- 4. Methods in Human Cytogenetics.- 5. Molecular Methods.- 6. Longitudinal Differentiation of Eukaryotic Chromosomes.- 7. Significance of Chromosome Bands.- 8. Architecture and Function of the Eukaryotic Chromosome.- 9. Chromosome Structural Aberrations.- 10. Causes of Chromosome Breakage.- 11. Chromosome Instability Syndromes.- 12. Sister Chromatid Exchanges and Mitotic Crossing-Over.- 13. Cell Fusion, Prematurely Condensed Chromosomes, and the Origin of Allocyclic Chromosomes.- 14. Chromosome Arrangement in Interphase and in Differentiated Nuclei.- 15. Modifications of Mitosis.- 16. Chromosomal Differentiation of Cells.- 17. Main Features of Meiosis.- 18. Details of Meiosis.- 19. Meiotic Abnormalities.- 20. Human Sex Determination and the Y Chromosome.- 21. Human X Chromosome.- 22. Abnormal Human Sex Chromosome Constitutions.- 23. Functional Structure of the Human X Chromosome.- 24. Numerically Abnormal Chromosome Constitutions in Humans.- 25. Structurally Abnormal Human Autosomes.- 26. Reciprocal Translocations.- 27. Robertsonian Translocations.- 28. Double Minutes and Homogeneously Stained Regions.- 29. Chromosomes and Oncogenes.- 30. Chromosomal Development of Cancer.- 31. Mapping of Human Chromosomes.- Index of Names.