Uversky / Lyubchenko Bio-nanoimaging

Protein Misfolding and Aggregation
1. Auflage 2013
ISBN: 978-0-12-397821-9
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 552 Seiten

Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and characterization of misfolded and aggregated protein species. The book is divided into three sections covering: - Nanotechnology and nanoimaging technology, including cryoelectron microscopy of beta(2)-microglobulin, studying amyloidogensis by FRET; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, including fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation processes, including multiple pathways of lysozyme aggregation, misfolded intermediate of a PDZ domain, and micelle formation by human islet amyloid polypeptide Protein misfolding and aggregation is a fast-growing frontier in molecular medicine and protein chemistry. Related disorders include cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and numerous neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoimaging technology has proved crucial in understanding protein-misfolding pathologies and in potential drug design aimed at the inhibition or reversal of protein aggregation. Using these technologies, researchers can monitor the aggregation process, visualize protein aggregates and analyze their properties. - Provides practical examples of nanoimaging research from leading molecular biology, cell biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs - Includes over 200 color images to illustrate the power of various nanoimaging technologies - Focuses on nanoimaging techniques applied to protein misfolding and aggregation in molecular medicine

Autoren/Hrsg.

Uversky, Vladimir N

Lyubchenko, Yuri

Leseproben

Contributors

Marie-Isabel Aguilar,     Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia

Maria Andreasen,     Interdisciplinary Nanoscience Center (iNANO), Center for Insoluble Protein Structures (inSPIN), Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

Neil R. Anthony,     Department of Physics, Emory University, Atlanta, GA, USA

Fernando Teran Arce,     Departments of Bioengineering and of Mechanical and Aerospace Engineering, and Materials Science Program, University of California, San Diego, La Jolla, CA, USA

Florian Arnhold,     IUF – Leibniz Research Institute of Environmental Medicine at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

Shruti Arya,     Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Mohali, Knowledge City, S.A.S Nagar, Mohali, Punjab, India

Aida Attar,     Department of Neurology, David Geffen School of Medicine, Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA

Silvia Barbosa,     Colloids and Polymers Physics Group, Condensed Physics Matter Group, Faculty of Physics, University of Santiago de Compostela, Spain

Manja A. Behrens,     Interdisciplinary Nanoscience Centre (iNANO) and Department of Chemistry, University of Aarhus, Aarhus, Denmark

Innocent B. Bekard,     Department of Chemical and Biomolecular Engineering, University of Melbourne, Parkville, Victoria, Australia; CSL Limited, Broadmeadows, Victoria, Australia

Georges Belfort,     Howard P Isermann Department of Chemical and Biological Engineering, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA

Martin L. Bennink,     Nanobiophysics, MESA & Institute for Nanotechnology and MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands

Magdalena Bereza,     Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, Hans Knöll-Institut, Jena, Germany

Keith M. Berland,     Department of Physics, Emory University, Atlanta, GA, USA

Gal Bitan,     Department of Neurology, David Geffen School of Medicine, Brain Research Institute, Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA, USA

Mischa Bonn,     Max Planck Institute for Polymer Research, Department of Molecular Spectroscopy, Mainz, Germany

Hugo M. Botelho

Instituto Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal

current address: BioISI - Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Portugal

Joana Branco dos Santos,     Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisboa, Portugal

Leonid Breydo,     Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA

Yi Cao,     National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, Nanjing, China

Roberto Cappai,     Department of Pathology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, Australia

Isabel Cardoso

Instituto Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal, Molecular Neurobiology Unit, Instituto de Biologia Molecular e Celular, Porto, Portugal

Escola Superior Tecnologia Saúde Porto, Instituto Politécnico do Porto, Vila Nova de Gaia, Portugal

Mariano Carrión-Vázquez

Instituto Cajal, IC-CSIC & Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA-Nanociencia), Cantoblanco, Madrid, Spain

Sofia B. Carvalho,     Instituto Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal

John A. Carver,     Research School of Chemistry, The Australian National University, Canberra, Australia

Fiona T.S. Chan,     Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

W. Seth Childers

Center for Fundamental and Applied Molecular Evolution, Departments of Chemistry and Biology, Emory University, Atlanta, GA, USA.

Current address: Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA

Jason C. Collins,     Old Dominion University, Department of Chemistry and Biochemistry, Norfolk, VA, USA

Laura Connelly,     Departments of Bioengineering and of Mechanical and Aerospace Engineering, and Materials Science Program, University of California, San Diego, La Jolla, CA, USA

Cyril Curtain,     Department of Pathology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, Australia, and Mental Health Research Institute of Victoria, University of Melbourne, Victoria, Australia

Vijit Dalal,     Department of Biological Sciences, Indian Institute of Science Education and Research (IISER), Mohali, Knowledge City, S.A.S Nagar, Mohali, Punjab, India

Alfonso De Simone,     Division of Molecular Biosciences, Imperial College London, London, United Kingdom, and Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

Athene M. Donald,     Sector of Biological and Soft Systems, Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom

Dave E. Dunstan,     Department of Chemical and Biomolecular Engineering, University of Melbourne, Parkville, Victoria, Australia; CSL Limited, Broadmeadows, Victoria, Australia

Heath Ecroyd,     Illawarra Health and Medical Research Institute and School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia

Jan Johannes Enghild,     Interdisciplinary Nanoscience Center (iNANO), Center for Insoluble Protein Structures (inSPIN), Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

Laura Esther Abelleira

Instituto Cajal, IC-CSIC & Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA-Nanociencia), Cantoblanco, Madrid, Spain

Marcus Fändrich,     Institute for Pharmaceutical Biotechnology, Ulm University, Ulm, Germany

María del Carmen Fernández-Ramírez

Instituto Cajal, IC-CSIC & Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA-Nanociencia), Cantoblanco, Madrid, Spain

Vito Foderà,     Sector of Biological and Soft Systems, Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom

Günter Fritz,     Department of Neuropathology, University of Freiburg, Germany

Yoshiaki Furukawa,     Laboratory for Mechanistic Chemistry of Biomolecules, Department of Chemistry, Keio University, Yokohama, Kanagawa, Japan

Shirin D. Ghodke,     Centre for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Centre (iNANO) and Department of Molecular Biology and Genetics, University of Aarhus, Aarhus, Denmark; Present...