Uversky / Lyubchenko Bio-nanoimaging

Protein Misfolding & Aggregation
1. Auflage 2013
ISBN: 978-0-12-397821-9
Verlag: Elsevier Reference Monographs
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 552 Seiten

Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and characterization of misfolded and aggregated protein species. The book is divided into three sections covering: - Nanotechnology and nanoimaging technology, including cryoelectron microscopy of beta(2)-microglobulin, studying amyloidogensis by FRET; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, including fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation processes, including multiple pathways of lysozyme aggregation, misfolded intermediate of a PDZ domain, and micelle formation by human islet amyloid polypeptide Protein misfolding and aggregation is a fast-growing frontier in molecular medicine and protein chemistry. Related disorders include cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and numerous neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoimaging technology has proved crucial in understanding protein-misfolding pathologies and in potential drug design aimed at the inhibition or reversal of protein aggregation. Using these technologies, researchers can monitor the aggregation process, visualize protein aggregates and analyze their properties.
Provides practical examples of nanoimaging research from leading molecular biology, cell biology, protein chemistry, biotechnology, genetics, and pharmaceutical labsIncludes over 200 color images to illustrate the power of various nanoimaging technologies Focuses on nanoimaging techniques applied to protein misfolding and aggregation in molecular medicine

Autoren/Hrsg.

Uversky, Vladimir

Lyubchenko, Yuri

Leseproben

Contributors
Marie-Isabel Aguilar,     Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia Maria Andreasen,     Interdisciplinary Nanoscience Center (iNANO), Center for Insoluble Protein Structures (inSPIN), Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark Neil R. Anthony,     Department of Physics, Emory University, Atlanta, GA, USA Fernando Teran Arce,     Departments of Bioengineering and of Mechanical and Aerospace Engineering, and Materials Science Program, University of California, San Diego, La Jolla, CA, USA Florian Arnhold,     IUF – Leibniz Research Institute of Environmental Medicine at Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany Shruti Arya,     Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Mohali, Knowledge City, S.A.S Nagar, Mohali, Punjab, India Aida Attar,     Department of Neurology, David Geffen School of Medicine, Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA Silvia Barbosa,     Colloids and Polymers Physics Group, Condensed Physics Matter Group, Faculty of Physics, University of Santiago de Compostela, Spain Manja A. Behrens,     Interdisciplinary Nanoscience Centre (iNANO) and Department of Chemistry, University of Aarhus, Aarhus, Denmark Innocent B. Bekard,     Department of Chemical and Biomolecular Engineering, University of Melbourne, Parkville, Victoria, Australia; CSL Limited, Broadmeadows, Victoria, Australia Georges Belfort,     Howard P Isermann Department of Chemical and Biological Engineering, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA Martin L. Bennink,     Nanobiophysics, MESA & Institute for Nanotechnology and MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands Magdalena Bereza,     Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie, Hans Knöll-Institut, Jena, Germany Keith M. Berland,     Department of Physics, Emory University, Atlanta, GA, USA Gal Bitan,     Department of Neurology, David Geffen School of Medicine, Brain Research Institute, Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA, USA Mischa Bonn,     Max Planck Institute for Polymer Research, Department of Molecular Spectroscopy, Mainz, Germany Hugo M. Botelho Instituto Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal current address: BioISI - Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Portugal Joana Branco dos Santos,     Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisboa, Portugal Leonid Breydo,     Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA Yi Cao,     National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, Nanjing, China Roberto Cappai,     Department of Pathology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, Australia Isabel Cardoso Instituto Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal, Molecular Neurobiology Unit, Instituto de Biologia Molecular e Celular, Porto, Portugal Escola Superior Tecnologia Saúde Porto, Instituto Politécnico do Porto, Vila Nova de Gaia, Portugal Mariano Carrión-Vázquez Instituto Cajal, IC-CSIC & Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA-Nanociencia), Cantoblanco, Madrid, Spain Sofia B. Carvalho,     Instituto Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal John A. Carver,     Research School of Chemistry, The Australian National University, Canberra, Australia Fiona T.S. Chan,     Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom W. Seth Childers Center for Fundamental and Applied Molecular Evolution, Departments of Chemistry and Biology, Emory University, Atlanta, GA, USA. Current address: Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA Jason C. Collins,     Old Dominion University, Department of Chemistry and Biochemistry, Norfolk, VA, USA Laura Connelly,     Departments of Bioengineering and of Mechanical and Aerospace Engineering, and Materials Science Program, University of California, San Diego, La Jolla, CA, USA Cyril Curtain,     Department of Pathology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, Australia, and Mental Health Research Institute of Victoria, University of Melbourne, Victoria, Australia Vijit Dalal,     Department of Biological Sciences, Indian Institute of Science Education and Research (IISER), Mohali, Knowledge City, S.A.S Nagar, Mohali, Punjab, India Alfonso De Simone,     Division of Molecular Biosciences, Imperial College London, London, United Kingdom, and Department of Chemistry, University of Cambridge, Cambridge, United Kingdom Athene M. Donald,     Sector of Biological and Soft Systems, Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom Dave E. Dunstan,     Department of Chemical and Biomolecular Engineering, University of Melbourne, Parkville, Victoria, Australia; CSL Limited, Broadmeadows, Victoria, Australia Heath Ecroyd,     Illawarra Health and Medical Research Institute and School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia Jan Johannes Enghild,     Interdisciplinary Nanoscience Center (iNANO), Center for Insoluble Protein Structures (inSPIN), Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark Laura Esther Abelleira Instituto Cajal, IC-CSIC & Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA-Nanociencia), Cantoblanco, Madrid, Spain Marcus Fändrich,     Institute for Pharmaceutical Biotechnology, Ulm University, Ulm, Germany María del Carmen Fernández-Ramírez Instituto Cajal, IC-CSIC & Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA-Nanociencia), Cantoblanco, Madrid, Spain Vito Foderà,     Sector of Biological and Soft Systems, Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom Günter Fritz,     Department of Neuropathology, University of Freiburg, Germany Yoshiaki Furukawa,     Laboratory for Mechanistic Chemistry of Biomolecules, Department of Chemistry, Keio University, Yokohama, Kanagawa, Japan Shirin D. Ghodke,     Centre for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Centre (iNANO) and Department of Molecular Biology and Genetics, University of Aarhus, Aarhus, Denmark; Present...