van de Velde / Schornagel Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2

Erscheinungsjahr 2013
ISBN: 978-1-4899-0218-4
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 358 Seiten, eBook

Zielgruppe

Research

Autoren/Hrsg.

van de Velde, Steef

Schornagel, J.H.

Inhaltsverzeichnis

Synthesis and Activity of Platinum Compounds.- NMR Spectroscopy of Platinum Drugs: From DNA to Body Fluids.- Trans-Diamminedichloroplatinum (II) Is Not an Antitumor Drug: Why?.- Iminoethers as Carrier Ligands: A Novel trans-Platinum Complex Possessing in Vitro and in Vivo Antitumor Activity.- Molecular Dynamics Simulations on Cisplatin Adducts with Dinucleotides.- Orally Active DACH-Pt (IV) Compounds.- Clinical Pharmacology.- Pharmacokinetic — Pharmacodynamic Relationships.- Clinical Pharmacology of Carboplatin Administered in Alternating Sequence with Paclitaxel in Patients with Non-Small Cell Lung Cancer: A European Cancer Centre (ECC) Study.- The Clinical Development of the Oral Platinum Anticancer Agent JM216.- Biochemistry and Molecular Pharmacology.- Membrane Transport of Platinum Compounds.- Detection of Adducts Formed upon Treatment of DNA with Cisplatin and Carboplatin.- Detection of Platinum Lesions at the Nucleotide Level in Cells using Single Strand Ligation PCR.- A Review of the Modulation of Cisplatin Toxicities by Chemoprotectants.- Combination Therapy with Cisplatinum and EGF Receptor Blockade.- Clinical Studies.- Oxaliplatin: Update on a Active and Safe Dach Platinum Complex.- Combination of Different Platinum Compounds: Issues, Strategies and Experience.- Phase I and II Studies with Lobaplatin.- Phase I Trials of Ormaplatin (NSC 363812).- 254-S, NK121 and TRK710.- Clinical Trials of Oxaliplatin and DWA2114R.- Incorporating Assessments of Sequence-Dependence in Developmental Studies of Combination Chemotherapy Regimens Containing New Agents and Platinum Compounds.- Review of Carboplatin-Based High-Dose Chemotherapy Combinations in the Autotransplant Setting.- Treatment Intensification in Germ-Cell Tumours.- IL-1? Enhancement of Platinum-MediatedAnti-Tumor Activity.- Non-Platinum Metal Complexes.- Overview of Tumor-Inhibiting Non-Platinum Complexes.- How does Platinum Kill the Cell?.- The Cisplatin-Induced Cellular Injury Response.- The Interaction of Cisplatin with Signal Transduction Pathways and the Regulation of Apoptosis.- Cell Cycle Checkpoints and Cancer Chemotherapy.- Controversy Session: Cisplatin vs Carboplatin?.- Carboplatin versus Cisplatin in the Chemotherapy of Solid Tumors: Pro-Carboplatin.- Cisplatin and Carboplatin in Testis and Ovarian Cancer: Pro Cisplatin.- Resistance.- Hypersensitivity to Cisplatin in Mouse Leukemia L1210/0 Cells: An XPG DNA Repair Defect.- DNA Repair and the Carrier Ligand Specificity of Platinum Resistance.- Transcription Factor Differences in Cisplatin Resistant Cells.