Villa / Veiga Crespo Enzybiotics

Antibiotic Enzymes as Drugs and Therapeutics
1. Auflage 2010
ISBN: 978-0-470-57053-1
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 272 Seiten, E-Book

Presents the latest research and applications for a new,promising approach to fighting infectious diseases
Enzybiotics is a promising way of fighting bacterial or fungalinfectious diseases by using viruses or viral-derived lysins.Drawing from the fields of medicinal chemistry, microbiology,genetics, and biochemistry, this book presents the state of thescience in enzybiotics research, fully exploring its emergingtherapeutic applications.
The book begins with four chapters that review the potentialapplications, possible advantages, and phylogeny of enzybiotics.Next, the book explores:
* A new approach to controlling infections using Gram-negativebacteria
* Bacteriophage holins and their membrane-disrupting activity
* Anti-staphylococcal lytic enzymes
* Membrane-targeted enzybiotics
* Design of phage cocktails for therapy from a host-range point ofview
* Novel methods to identify new enzybiotics
* Genetically modified phages that deliver suicidal genes totarget bacteria
The authors, all active enzybiotics researchers, offer a varietyof perspectives, the benefit of their own hands-on investigations,as well as a thorough review and analysis of the currentliterature.
As more and more bacteria become resistant to antibiotics, thedevelopment of new disease-fighting agents has become essential.This book demonstrates the full potential of the emerging field ofenzybiotics to control infectious diseases. Moreover, it will serveas a springboard for new research and the development of newtherapeutics.

Autoren/Hrsg.

Villa, Tomas G.

Veiga Crespo, Patricia

Inhaltsverzeichnis

PREFACE.
CONTRIBUTORS.
1 ENZYBIOTICS AND THEIR POTENTIAL APPLICATIONS IN MEDICINE(Jan Borysowski and Andrzej Górski).
2 ADVANTAGES AND DISADVANTAGES IN THE USE OF ANTIBIOTICS ORPHAGES AS THERAPEUTIC AGENTS (Patricia Veiga-Crespo and Tomas G.Villa).
3 ENZYBIOTICS AS SELECTIVE KILLERS OF TARGET BACTERIA (JuanC. Alonso and Marcelo E. Tolmasky).
4 PHYLOGENY OF ENZYBIOTICS (Patricia Veiga-Crespo and TomasG. Villa).
5 BACTERIOPHAGE LYSINS: THE ULTIMATE ENZYBIOTIC (Vincent A.Fischetti).
6 BACTERIOPHAGE HOLINS AND THEIR MEMBRANEDISRUPTING ACTIVITY(María Gasset).
7 ANTI-STAPHYLOCOCCAL LYTIC ENZYMES (Jan Borysowski andAndrzej Górski).
8 MEMBRANE-TARGETED ENZYBIOTICS (María Gasset).
9 DESIGN OF PHAGE COCKTAILS FOR THERAPY FROM A HOST RANGE POINTOF VIEW (Lawrence D. Goodridge).
10 IDENTIFYING PHAGE LYTIC ENZYMES: PAST, PRESENT, AND FUTURE(Jonathan E. Schmitz, Raymond Schuch, and Vincent A.Fischetti).
11 USE OF GENETICALLY MODIFIED PHAGES TO DELIVER SUICIDAL GENESTO TARGET BACTERIA (Lawrence D. Goodridge).
CONCLUDING REMARKS: THE FUTURE OF ENZYBIOTICS (PatriciaVeiga-Crespo and Tomas G. Villa).
INDEX.

Über Autor(innen)

Tomas G. Villa, PhD, is Full Professor of Microbiology andChair of the Department of Microbiology at the University ofSantiago de Compostela, Faculty of Pharmacy (Spain). Dr. Villa haswritten twenty book chapters and over 160 papers. In addition, hehas translated into Spanish several microbiology text books. Dr.Villa is regularly engaged in the teaching of microbiology andbiotechnology.
Patricia Veiga-Crespo, PhD, is Lecturer of Microbiologyand works in the Department of Microbiology at the University ofSantiago de Compostela, where she is involved in the study ofmulti-resistance phenomena and enzybiotics and the teaching ofadvanced biotechnology and basic microbiology.