Wang / Slikker, Jr. Neural Cell Biology

1. Auflage 2017
ISBN: 978-1-4987-2601-6
Verlag: CRC Press
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 347 Seiten

This book delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text reviews and discusses approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. The book intends to elaborate functional outcomes of component-to-component relationships using rodent and nonhuman primate in vitro and in vivo models that allow for the directional and quantitative description of the complete organism in response to environmental perturbations. In addition, attention has also been directed to some of the more recent methodologies, including genomics, proteomics and metabolomics, applied in the evolutionary neurobiological field.

Zielgruppe

This book is intended for neurobiologists, pathologists, pharmacologists, and toxicologists. It also would be useful to anyone associated with a regulatory agency.

Autoren/Hrsg.

Wang, Cheng

Slikker, Jr., William

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Neurons -- Nerve Cells

Fang Liu, Tucker A. Patterson, Jingshu Zhang, Merle G. Paule, William Slikker, Jr. and Cheng Wang

Astrocytes

Cheng Wang, Qi Yin, Shuliang Liu, Xuan Zhang, Fang Liu, Jingshu Zhang, Tucker A. Patterson, Merle G. Paule and William Slikker, Jr.

Oligodendrocytes [myelin-related glial cell in the central nervous system (CNS)]

Shuliang Liu, Merle G. Paule, Fang Liu, Qi Yin, Tucker A. Patterson, William Slikker, Jr. and Cheng Wang

Schwann Cells

Xuan Zhang, Tucker A. Patterson, Merle G. Paule, Cheng Wang and William Slikker, Jr.

Neuroendocrine Cells

Zhen He, Sherry A. Ferguson, Tucker A. Patterson and Merle G. Paule

Neural Stem Cells in the Adult Brain: Altered Activity in Aging, Alzheimer’s Disease, Mood Disorders and Epilepsy

Ashok K. Shetty and Bharathi Hattiangady

Neural Stem Cells and Transplantation

Malathi Srivatsan

3D in vitro Models for Developmental Neurotoxicity (DNT)

Luc Stoppini, Jenny Sandström von Tobel, Igor Charvet, Marie-Gabrielle Zurich, Lars Sundstrom and Florianne Monnet-Tschudi

Neural Cell Lines (Lineage)

Qiang Gu

Advanced Cell Techniques to Study Developmental Neurobiology and Toxicology

Thomas Hartung, Helena T. Hogberg, Marcel Leist, David Pamies and Lena Smirnova

Anesthesia and Neural Plasticity

Laszlo Vutskits

Blood-Brain Barrier (BBB)

Balabhaskar Prabhakarpandian, Syed Ali and Kapil Pant

Neurotrophins and Alzheimer’s Disease

Jyotshna Kanungo

Neurotransmitters and Receptors

Vesna Jevtovic-Todorovic

15. Neuronal Ion Channels

Slobodan M. Todorovic

16. Brain Injury - Neuroprotection

Koichi Yuki, Mary Ellen McCann and Sulpicio G. Soriano

Über Autor(innen)

Cheng Wang, Ph.D, is a senior scientist at the National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. He also is an adjunct faculty member of the Department of Pharmacology and Toxicology at the University of Arkansas for Medical Sciences (UAMS), Little Rock, USA.

Dr. William Slikker is a recognized expert in neurotoxicology and the director of the National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas.