Yang / Yeh / McCarthy Enzyme Technologies

Pluripotent Players in Discovering Therapeutic Agent
1. Auflage 2013
ISBN: 978-1-118-73989-1
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 356 Seiten, E-Book

Reihe: Chemical Biology of Enzymes for Biotechnology and Pharmaceutical Applications

Sets the stage for advances in drug discovery using thelatest enzyme technology
Reviewing new and emerging applications of enzyme technology indrug discovery, this book highlights some of the most promisingareas of pharmaceutical and biotechnology research. It coversenzyme assay technology, utilization of enzymology for prodrugdesign, and the application of enzymes as therapeutic agents.Expert reviews highlight how our latest understanding of enzymologyis used to develop new practical applications in drug discovery anddesign.
Filled with case studies, Enzyme Technologies: PluripotentPlayers in Discovering Therapeutic Agents enables readers tobetter understand the diverse functions of enzymes and masterspecific applications in drug discovery research. In addition tosmall molecule drug discovery, the book explores new developmentsin enzymes as therapeutic agents for genetic disorders.
* Section A, Enzymes - Essential Workhorses inPharmaceutical Research, offers support in selecting the bestenzyme targets for drug discovery, designing enzyme inhibitors fortherapeutic agents, and evaluating selective enzymeinhibitors.
* Section B, Enzymes - Indispensable Tools for ImprovingDruggability, sets forth the principles alongside real-worldexamples of exploiting specific properties of enzymes to designsuccessful prodrugs.
* Section C, Enzymes - Powerful Weapons for CorrectingNature's Errors, provides new insights on applying enzymes astherapeutic agents or diagnostic tools to treat geneticdisorders.
Chapters are contributed by leading experts from around theworld. Their contributions are based on a thorough review of thecurrent literature as well as their own research.
Reviewing our latest understanding of the nature of enzymes andtheir role in drug discovery, this book is recommended forresearchers in pharmaceuticals and biotechnology as well as forresearchers in enzymology, biochemistry, molecular biology, andmedicinal chemistry.

Autoren/Hrsg.

Yang, Hsiu-Chiung

Yeh, Wu-Kuang

McCarthy, J. R.

Inhaltsverzeichnis

Contributors vii
Preface ix
Part A _Enzymes - essential workhorses inpharmaceutical research 1
1 Assay Technologies for Proteases 3
Anuradha Roy, Gerald H. Lushington, James McGee, and RathnamChaguturu
2 Discovery and Development of Isozyme-Selective InhibitorsInvolved in Lipid Metabolism 55
Taichi Ohshiro and Hiroshi Tomoda
3 Covalent Enzyme Inhibition in Drug Discovery and Development81
Shujaath Mehdi
4 Preclinomics: Enzyme Assays and Rodent Models for Metabolicdiseases 131
Wu-Kuang Yeh and Richard G. Peterson
Part B _Enzymes - indispensable tools forimproving druggability 163
5 Enzymes and Targeted Activation of Prodrugs 165
Yanhui Yang, Yu Chen, Herve Aloysius, Daigo Inoyama, and LongqinHu
6 Evolution of an Orally Active Prodrug of Gemcitabine 237
James R. McCarthy
7 Enzymatically Activated Phosphate and Phosphonate Prodrugs253
Ivan S. Krylov and Charles E. McKenna
Part C E nzymes - powerful weapons for correctingNature's errors 301
8 Treatment Options for Mucopolysaccharidosis Type II(Hunter's Syndrome) 303
Michael Beck
9 Enzyme Replacement Therapy for Fabry Disease 321
Ley Nadine Lacbawan, Wei Zheng, and Ozlem Goker-Alpan
10 Methods and Principles of Pancreatic Function Tests 335
Henrike von Schassen, Jutta Keller, and Peter Layer
Index 341

Über Autor(innen)

HSIU-CHIUNG YANG, PhD, is Research Advisor at Eli Lillyand Company. She is the author or coauthor of over fortypublications and holder of two patents.
WU-KUANG YEH, PhD, is Adjunct Professor at IndianaUniversity Purdue University Indianapolis (IUPUI), and was Directorof Research and Principal Investigator at PreClinOmics, Inc. Theholder of six U.S. patents, Dr. Yeh is the author or coauthor ofover 115 publications.
JAMES R. McCARTHY, PhD, is Research Professor in thedepartment of chemistry and chemical biology at Indiana UniversityPurdue University Indianapolis (IUPUI), and was a DistinguishedResearch Fellow at Eli Lilly and Company. He is the author orcoauthor of over 130 publications and holder of over sixtypatents.