Yoshida / Hagihara / Ebashi Biochemical Immunological Pharmacology

Proceedings of the 8th International Congress of Pharmacology, Tokyo, 1981
1. Auflage 2016
ISBN: 978-1-4831-4849-6
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 288 Seiten, Web PDF

Advances in Pharmacology & Therapeutics II, Volume 4: Biochemical Immunological Pharmacology covers papers on the developments in pharmacology and therapeutics. The book contains invited lectures on the effect of drugs on immunological control mechanisms; the pharmacology of specific, pure and potent serotonin 5-HT2 or S2-antagonists; and the pharmacology of phospholipases A2 isolated from snake venoms. The text also contains papers on leukotrienes; the guanine nucleotide-binding regulatory component of adenylate cyclase; and the pharmacological and toxicological implications of multiple cytochromes P-450. The impact of the emerging biotechnologies on pharmacology; the action of antipsychotics on LSD-induced neurochemical and behavioral effects in rats; and the effect of histamine and related compounds on the immune response are also considered. The book also presents papers on inflammation; prostacyclin; prostaglandins; and chemical hazards to humans.

Autoren/Hrsg.

Yoshida, H.

Hagihara, Y.

Ebashi, S.

Inhaltsverzeichnis

1;Front Cover;1
2;Biochemical Immunological Pharmacology;4
3;Copyright Page;5
4;Table of Contents;6
5;Introduction;8
6;PART 1: INVITED LECTURE;10
7;Chapte 1. The Effect of Drugs on Immunological Control Mechanisms;12
7.1;ABSTRACT;12
7.2;KEYWORDS;12
7.3;INTRODUCTION;13
7.4;A. DIRECT ENHANCEMENT OF LYMPHOCYTE ACTIVITY;15
7.5;B.ACTION OF SUPPRESSOR MECHANISMS;19
7.6;REFERENCES;24
8;Chapte 2. The Pharmacology of Specific, Pure and Potent Serotonin 5-HT2 or S2-Antagonists;30
8.1;ABSTRACT;30
8.2;KEYWORDS;30
8.3;INTRODUCTION;30
8.4;THE PHARMACOLOGICAL PROFILE OF KETANSERIN AND ITS ANALOGUES;31
8.5;CLINICAL RESPONSES TO KETANSERIN;38
8.6;CONCLUSIONS;41
8.7;REFERENCES;42
9;Chapte 3. The Pharmacology of Phospholipases A2 Isolated from Snake Venoms, with Particular Reference to Their Effects on Neuromuscular Transmission;46
9.1;ABSTRACT;46
9.2;KEYWORDS;46
9.3;INTRODUCTION;47
9.4;LETHALITY AND CAUSE OF DEATH;48
9.5;EFFECTS ON NEUROMUSCULAR TRANSMISSION IN SKELETAL MUSCLE;49
9.6;ACKNOWLEDGEMENTS;58
9.7;REFERENCES;58
10;Chapte 4. Leukotrienes: A New Group of Biologically Active Compounds;64
10.1;ABSTRACT;64
10.2;KEYWORDS;64
10.3;INTRODUCTION;64
10.4;DISCOVERY OF LEUKOTRIENES;65
10.5;STRUCTURE OF SRS-A;69
10.6;NOMENCLATURE;73
10.7;BIOLOGICAL EFFECTS OF LEUKOTRIENES;75
10.8;ACKNOWLEDGEMENT;82
10.9;REFERENCES;82
11;Chapte 5. The Guanine Nucleotide-binding Regulatory Component of Adenylate Cyclase;88
11.1;ABSTRACT;88
11.2;KEYWORDS;88
11.3;INTRODUCTION;88
11.4;RESULTS;89
11.5;CONCLUSIONS AND SUMMARY;102
11.6;ACKNOWLEDGEMENTS;103
11.7;REFERENCES;103
12;Chapte 6. Pharmacological and Toxicological Implications of Multiple Cytochromes P-450;108
12.1;ABSTRACT;108
12.2;KEYWORDS;108
12.3;SPECIFICITY IN THE REGULATION OF MONOOXYGENASE ACTIVITY IN RAT LIVER MICROSOMES;108
12.4;ISOLATION OF MULTIPLE CYTOCHROMES P-450;110
12.5;EFFECTS OF ENZYME INDUCTION ON THE TOXICITY OF CHEMICALS;113
12.6;EFFECT OF ENZYME INDUCTION ON THE METABOLISM OF STEROIDS AND OTHER ENDOGENOUS SUBSTRATES;114
12.7;CIGARETTE SMOKING AND THE BIOTRANSFORMATION OF CHEMICALS IN MAN;115
12.8;DIET AND THE BIOTRANSFORMATION OF CHEMICALS IN MAN;117
12.9;MULTIPLE MONOOXYGENASES IN HUMAN LIVER;117
12.10;ACKNOWLEDGEMENT;120
12.11;REFERENCES;120
13;Chapte 7. The Impact of the Emerging Biotechnologies on Pharmacology;130
13.1;ABSTRACT;130
13.2;KEYWORDS;130
13.3;MONOCLONAL ANTIBODIES;131
13.4;MONOCLONAL ANTIBODIES AND PHARMACOLOGY;133
13.5;RECOMBINANT DNA TECHNOLOGY;133
13.6;RECOMBINANT DNA AND PHARMACOLOGY;135
13.7;REFERENCES;140
14;PART 2: SYMPOSIUM;144
15;Chapte 8. Action of Antipsychotics on LSD-induced Neurochemical and Behavioural Effects in Rats;146
15.1;ABSTRACT;146
15.2;KEYWORDS;146
15.3;INTRODUCTION;146
15.4;METHODS;147
15.5;BEHAVIOURAL STUDIES;147
15.6;NEUROCHEMICAL STUDIES;150
15.7;CONCLUSIONS;153
15.8;REFERENCES;153
16;Chapte 9. Calmodulin and Dopamine Receptor Regulation;156
16.1;ABSTRACT;156
16.2;KEYWORDS;156
16.3;INTRODUCTION;156
16.4;CONCLUSION;162
16.5;REFERENCES;163
17;Chapte 10. Effect of Histamine and Related Compounds on the Immune Response;168
17.1;ABSTRACT;168
17.2;KEYWORDS;168
17.3;INTRODUCTION;168
17.4;ACKNOWLEDGEMENTS;177
17.5;REFERENCES;177
18;Chapte 11. Inflammatory Mediators Derived from the Complement System;180
18.1;ABSTRACT;180
18.2;KEYWORDS;180
18.3;INTRODUCTION;180
18.4;METHODS OF MEASURING OEDEMA FORMATION;181
18.5;PROSTAGLANDINS;181
18.6;COMPLEMENT;182
18.7;LEUKOCYTES;184
18.8;CONCLUSION;186
18.9;REFERENCES;187
19;Chapte 12. Studies on the Mechanism of Action of D-Penicillamine in Rheumatoid Arthritis;190
19.1;ABSTRACT;190
19.2;KEYWORDS;190
19.3;INTRODUCTION;191
19.4;METHODS;191
19.5;RESULTS;192
19.6;DISCUSSION;197
19.7;ACKNOWLEDGMENTS;198
19.8;REFERENCES;198
20;Chapte 13. Pain and Inflammation: a New Concept;202
20.1;ABSTRACT;202
20.2;KEY WORDS;202
20.3;INTRODUCTION;202
20.4;METHODS AND RESULTS;204
20.5;DISCUSSION;204
20.6;REFERENCES;204
21;Chapte 14. Glucocorticoids as Anti-inflammatory Agents;206
21.1;ABSTRACT;206
21.2;KEYWORDS;206
21.3;INTRODUCTION;206
21.4;THE INHIBITION OF PG RELEASE;207
21.5;THE ANTI-PHOSPHOLIPASE EFFECT;207
21.6;THE GENE EXPRESSION HYPOTHESIS;208
21.7;THE SECOND MESSENGER HYPOTHESIS;209
21.8;CONCLUSION;210
21.9;REFERENCES;211
22;Chapte 15. Inhibition of Inflammatory Action of Leukotriene C and D and PGE by Glucocorticoids;214
22.1;ABSTRACT;214
22.2;KEYWORDS;214
22.3;INTRODUCTION;215
22.4;POSITIVE CORRELATION OF C0RTIC0ID-INDUCED SUPPRESSION OF PGE WITH SUPPRESSION OF EXUDATIVE PROCESS;215
22.5;DIRECT BLOCKADE BY DEXAMETHSONE OF INFLAMMATORY ACTIONS OF PGE, LTC AND LTD;216
22.6;COMPARISON OF THE ANTI-INFLAMMATORY EFFECTS OF DEXAMETHASONE WITH THOSE OF BW755C;217
22.7;CONCLUSION;218
22.8;ACKNOWLEDGMENT;218
22.9;REFERENCES;218
23;Chapte 16. Prostacyclin and Its Therapeutic Potential;224
23.1;ABSTRACT;224
23.2;KEY WORDS;224
23.3;REFERENCES;233
24;Chapte 17. Regulation of Prostacyclin (PGI2) Release into Circulation;244
24.1;ABSTRACT;244
24.2;KEY WORDS;244
24.3;INTRODUCTION;245
24.4;MATERIAL AND METHODS;246
24.5;RESULTS;247
24.6;DISCUSSION;252
24.7;REFERENCES;256
25;Chapte 18. Antithrombotic Action of Prostaglandins: Different Roles of Prostacyclin and PGD2;260
25.1;ABSTRACT;260
25.2;KEYWORDS;260
25.3;ACKNOWLEDGEMENT;268
25.4;REFERENCES;268
26;Chapte 19. Chemical Hazards to Man: General Considerations;270
27;Chapte 20. Acute and Chronic Changes in the Nigrostriatal Loop After Treatment with Antipsychotic Drugs;278
27.1;ABSTRACT;278
27.2;KEYWORDS;278
27.3;INTRODUCTION;278
27.4;ROLE OF GABA TRANSMISSION IN SUBSTANTIA NIGRA;279
27.5;INHIBITION OF STRIATONIGRAL GABA NEURONS BY INTRASTRIATAL GABA TRANSMISSION;281
27.6;ALTERATIONS INDUCED BY CHRONIC ANTIPSYCHOTIC DRUG TREATMENT;282
27.7;CHRONIC LOSS OF STRIATAL DA TRANSMISSION: RECIPROCAL EFFECTS ON STRIATAL AND NIGRAL GABA TURNOVER;283
27.8;CHRONIC ANTIPSYCHOTIC TREATMENT CAUSES AN INCREASE IN GABA RECEPTOR DENSITY IN SN;284
27.9;SUPERSENSITIVITY OF NIGRAL GABA RECEPTORS FOLLOWING CHRONIC LOSS OF STRIATAL DA TRANSMISSION: BEHAVIORAL STUDIES WITH INTRANIGRAL MUSCIM0L;285
27.10;CONCLUSIONS;287
27.11;REFERENCES;288
28;Index;274