E-Book, Englisch, 1658 Seiten, eBook
E-Book, Englisch, 1658 Seiten, eBook
ISBN: 978-0-387-87429-6
Verlag: Springer US
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
Zielgruppe
Professional/practitioner
Autoren/Hrsg.
Weitere Infos & Material
The Human Pulmonary Circulation: Historical Introduction.- Microcirculation of the Lung: Functional and Anatomic Aspects.- Pulmonary Vascular Development.- Pulmonary Vascular Function.- Pulmonary Vascular Mechanics.- Modeling of the Pulmonary Vasculature.- Metabolic and Clearance Function at the Pulmonary Microvascular Endothelial Surface in Pulmonary Hypertension.- The Pharmacology of the Major Vasoactive Mediators Relevant to the Pathogenesis of Pulmonary Hypertension.- The Normal Fetal and Neonatal Pulmonary Circulation.- Excitation-contraction Coupling and Regulation of Pulmonary Vascular Contractility.- Endothelial Regulation of Pulmonary Vascular Tone.- Acute Lung Injury: The Injured Lung Endothelium, Therapeutic Strategies for Barrier Protection and Vascular Biomarkers.- Ion Channels and Transporters in the Pulmonary Vasculature: A Focus on Smooth Muscle.- Receptor-mediated Signal Transduction and Cell Signaling.- Role of Calcium as a Second Messenger in Signaling: A Focus on Endothelium.- Caveolae and Signaling in Pulmonary Vascular Endothelial and Smooth Muscle Cells.- The Chemistry of Biological Gases.- Role of Oxygen-derived Species in the Regulation of Pulmonary Vascular Tone.- Mitochondrial ROS and Redox State in Pulmonary Vascular O2 Sensing.- Cellular and Molecular Mechanisms of Pulmonary Vascular Smooth Muscle Cell Proliferation.- Role of Ca2+ in Vascular Smooth Muscle Gene Expression and Proliferation.- Biochemistry and Cellular Mechanisms of Apoptosis in Vascular Smooth Muscle and Endothelial Cells.- The Coagulation Cascade and its Regulation.- Platelets in Pulmonary Vascular Physiology and Pathology.- Lysis and Organization of Pulmonary Thromboemboli.- Interactions of Leukocytes and Coagulation Factors with the Vessel Wall.- Interaction of the Plasminogen System with the Vessel Wall.- Endothelial Apoptosis and Repair in Pulmonary Arterial Hypertension.- Bronchial Arterial Circulation in the Human.- Animal Models of Pulmonary Hypertension.- Transgenic and Gene Targeted Mouse Models for Pulmonary Hypertension.- Animal Models of Increased Lung Vascular Permeability.- Isolation and Culture of Pulmonary Vascular Smooth Muscle and Endothelial Cells.- Conventional Patch Clamp Techniques and High-throughput Patch Clamp Recordings on a Chip for Measuring Ion Channel Activity.- Measurement of Pulmonary Vascular Structure and Pulmonary Blood Distribution by MDCT and MR Imaging Techniques.- Quantification of DNA, RNA and Protein Expression.- Gene Cloning, Transfection and Mutagenesis.- Approaches for Manipulation of Gene Expression.- Bioinformatics, Genomics, and Functional Genomics: Overview.- Genomic Application to Study Pulmonary Hypertension.- Proteomics and Functional Proteomics.- Maintenance, Propagation and Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells.- Identification of Adult Stem and Progenitor Cells in the Pulmonary Vasculature.- Differentiation of Embryonic Stem Cells to Vascular Cell Lineages.- Statistics and Clinical Data Analysis: A Reference Guide.- Hypoxic Pulmonary Vasoconstriction.- Pathogenic Roles of Ca2+ and Ion Channels in Hypoxia-mediated Pulmonary Hypertension.- Roles of Endothelium-derived Vasoactive and Mitogenic Factors in the Development of Chronic Hypoxia-mediated Pulmonary Hypertension.- Oxygen-sensitive Transcription Factors and Hypoxia-mediated Pulmonary Hypertension.- Developmental Regulation of Pulmonary Vascular Oxygen Sensing.- Pulmonary Vascular Remodeling by High Oxygen.- Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms.- Carbon Monoxide and Heme Oxygenase in the Regulation of Pulmonary Vascular Function and Structure.- Shear Stress, Cell Signaling and Pulmonary Vascular Remodeling.- Pulmonary Hypertension and the Extracellular Matrix.- Role of Progenitor Cells in Pulmonary Vascular Remodeling.- Receptor Signaling in Pulmonary Arterial Hypertension.- Role of Endothelium in the Development of Pulmonary Hypertension.- Coagulation and the Vessel Wall in Pulmonary Embolism.- Alveolar Epithelial Fluid Transport in Lung Injury.- High Altitude Pulmonary Edema .- Statins and Acute Lung Injury.- Genomics of Acute Lung Injury and Vascular Barrier Dysfunction.- Ventilator-induced Mechanical Stress and Lung Vascular Dysfunction.- Classification of Pulmonary Hypertension: History and Perspectives.- Epidemiology of Pulmonary Arterial Hypertension.- Air Pollution and the Pulmonary Vasculature.- Idiopathic Pulmonary Arterial Hypertension.- Genetics of Familial and Idiopathic Pulmonary Arterial Hypertension.- Pulmonary Arterial Hypertension Related to Scleroderma and Collagen Vascular Diseases.- Pathology and Management of Portopulmonary Hypertension.- Pathobiology and Treatment of Pulmonary Hypertension in HIV Disease.- Pulmonary Arterial Hypertension Secondary to Anorexigens and Other Drugs and Toxins.- Pulmonary Arterial Hypertension Related to Gauchers, Sarcoidosis and Other Disorders.- Pediatric Pulmonary Hypertension: An Integrated View from Pediatric Subspecialists.- Persistent Pulmonary Hypertension of the Newborn: Mechanisms and Treatment.- The Pulmonary Circulation in Congenital Heart Disease.- Pulmonary Hypertension Secondary to Congenital Systemic to Pulmonary (Left-to-Right) Shunts.- Surgical Evaluation of Congenital Heart Disease-associated Pulmonary Hypertension.- Pulmonary Veno-occlusive Disease.- Left Ventricular Diastolic Heart Function and Pulmonary Hypertension.- Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Diseases.- Pulmonary Hypertension Associated with Interstitial Lung Disease.- High Altitude Pulmonary Hypertension.- Pulmonary Hypertension and Congenital Heart Defects at High Altitude.- Pulmonary Embolism and Deep Vein Thrombosis.- Pulmonary Hypertension Due to Pulmonary Embolism and Thromboembolic Obstruction of Proximal and Distal Pulmonary Arteries.- Risk Factors for Chronic Thromboembolic Pulmonary Hypertension.- Evaluation of Small Vessel Arteriopathy in Chronic Thromboembolic Pulmonary Hypertension.- Hemolytic Anemia Associated Pulmonary Hypertension: Sickle Cell Disease and Thalassemia-associated Pulmonary Hypertension.- Pulmonary Hypertension due to Schistosomiasis.- Pulmonary Hypertension due to Capillary Hemangiomatosis.- Molecular Basis of Right Ventricular Hypertrophy and Failure in Pulmonary Vascular Disease.- Right Ventricular Dysfunction in Pulmonary Hypertension.- Large Vessel Pulmonary Arteritis.- Tumors of the Pulmonary Vascular Bed.- Cor Pulmonale.- Pregnancy and Contraception in Patients with Pulmonary Arterial Hypertension.- Cardiac Catheterization in the Patient with Pulmonary Hypertension.- Imaging of Pulmonary Vascular Diseases.- Histological and Pathological Diagnosis of Pulmonary Hypertension: Pathological Classification of Pulmonary Vascular Lesions.- Echocardiography in Pulmonary Vascular Disease.- Calcium Channel Blockers in the Treatment of Pulmonary Arterial Hypertension.- Prostacyclin and Prostaglandins.- Endothelin Receptor Antagonists for the Treatment of Pulmonary Arterial Hypertension.- Phosphodiesterase Inhibitors in the Treatment of Pulmonary Hypertension.- Nitric Oxide for Children.- The Serotonin System as a Therapeutic Target in Pulmonary Hypertension.- Combination Therapy for Pulmonary Arterial Hypertension.- Thrombolytic and Anti-coagulant Therapy for Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension.- Nursing Care of Patients with Pulmonary Arterial Hypertension.- Atrial Septostomy.- Evaluation of Patients with Chronic Pulmonary Thromboembolic Pulmonary Hypertension for Pulmonary Endarterectomy.- Pulmonary Endarterectomy.- Evaluation of Patients with Pulmonary Hypertension for Lung Transplantation.- Lung Transplantation for Pulmonary Hypertension.- Living-donor Lower Lobar Lung Transplantation for Pulmonary Arterial Hypertension.- Results of Lung Transplantation.- Index.