E-Book, Englisch, 240 Seiten
Zhao / Yang Statistical Methods in Drug Combination Studies
Erscheinungsjahr 2015
ISBN: 978-1-4822-1675-2
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
E-Book, Englisch, 240 Seiten
Reihe: Chapman & Hall/CRC Biostatistics Series
ISBN: 978-1-4822-1675-2
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
Drug combination research has become increasingly important as multi-drug treatments may overcome disease resistance to monotherapies given the heterogeneous nature of complex diseases, such as cancer. To screen for potential candidates, rigorous statistical methods must used to avoid a high proportion of false-positive recommendations, resulting in a tremendous waste of time and resources. This book covers all statistical aspects of drug combination research, from designing in vitro drug combination studies to analyzing clinical trial data.
Zielgruppe
Researchers involved in drug combination studies.
Autoren/Hrsg.
Weitere Infos & Material
Drug Combination: Much Promise and Many Hurdles. Drug Combination Synergy. Drug Combination Design Strategies. Confidence Interval for Interaction Index. Two-Stage Response Surface Approaches to Modeling Drug Interaction. A Bayesian Industry Approach to Phase I Combination Trials in Oncology. Statistical Methodology for Evaluation Combination Therapy in Clinical Trials. Challenges and Opportunities in Analysis of Drug Combination Clinical Trial Data. Statistical Computational Tools for ADA Analysis.
