OXIDATIVE STRESS

Erscheinungsjahr 2012
ISBN: 978-0-8412-2683-8
Verlag: AMER CHEMICAL SOC

Buch, Englisch, Band 1083, 438 Seiten, Format (B × H): 158 mm x 229 mm, Gewicht: 710 g

Reihe: ACS Symposium Series

Oxidative stress is the state of a diminished capacity of a biological system to counteract an overproduction or invasion of reactive oxygen species and other radicals. This book presents recent advancements in the understanding of oxidative stress, the mechanisms of damage to cells and biomolecules, and pathological implications in disorders including Alzheimer's disease, Parkinson's Disease, cardiovascular disease, cell damage in HIV-AIDS, stroke, autism and
premature aging. The book is a comprehensive source of information describing new directions in diagnostics of oxidative stress, including novel detection methods of oxidative-stress biomarkers, prevention by antioxidants, and therapy using novel free radical scavenging agents and natural defense
systems.

Zielgruppe

Academics and professionals in related fields

Autoren/Hrsg.

Andreescu, Silvana

Hepel, Maria

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie

Inhaltsverzeichnis

Preface
1. The Role of Antioxidants in Human Health
Saikat Sen and Raja Chakraborty
2. Pathophysiological Implications of Altered Redox Balance in HIV/AIDS Infection: Diagnosis and Counteract Interventions
L. Gil del Valle, Ph.D.
3. Thermodynamics of Free Radical Reactions and the Redox Environment of a Cell
Klaudia Jomova and Marian Valko
4. Oxidative Stress in the Metabolism of Estrogens Leading to Cancer Initiation: Prevention by Specific Antioxidants
Eleanor G. Rogan and Ercole L. Cavalieri
5. Polyphenol Compounds as Antioxidants for Disease Prevention: Reactive Oxygen Species Scavenging, Enzyme Regulation, and Metal Chelation Mechanisms in E. coli and Human Cells
Hsiao C. Wang and Julia L. Brumaghim
6. DNA-Protective Mechanisms of Glutathione Intervention in Catechol-Mediated Oxidative DNA Damage in the Presence of Copper(II) Ions
Maria Hepel, Magdalena Stobiecka, Janet Peachey, and Jeremiah Miller
7. Antioxidant Effectiveness in Preventing Paraquat-Mediated Oxidative Dna Damage in the Presence of H2O2
Magdalena Stobiecka, Amanda Prance, Kaitlin Coopersmith, and Maria Hepel
8. Artificial Nanoparticle Antioxidants
Erica Sharpe, Daniel Andreescu, and Silvana Andreescu
9. Cerium Oxide Nanoparticles for the Treatment of Neurological Oxidative Stress Diseases
A. Y. Estevez and J. S. Erlichman
10. Detection of Superoxide and Hydrogen Peroxide from Living Cells Using Electrochemical Sensors
Szilveszter Gáspár
11. Peroxynitrite and Nitroxidative Stress: Detection Probes and Micro-Sensors. A Case of a Nanostructured Catalytic Film
Serban F. Peteu, Saleem Banihani, Mutha M. Gunesekera, Pubudu Peiris, Oana A. Sicuia, and Mekki Bayachou
12. Blue Native PAGE and Mass Spectrometry as an Approach for the Investigation of Stable and Transient Protein-Protein Interactions
Alisa G. Woods, Izabela Sokolowska, Rama Yakubu, Melissa Butkiewicz, Martin LaFleur, Christopher Talbot, and Costel C. Darie
13. Mass Spectrometry for Proteomics-Based Investigation of Oxidative Stress and Heat Shock Proteins
Izabela Sokolowska, Alisa G. Woods, Jessica Wagner, Jeannette Dorler, Kelly Wormwood, Johannes Thome, and Costel C. Darie
Editors' Biographies
Author Index
Subject Index

Über Autor(innen)

Andreescu, Silvana
Silvana Andreescu is Associate professor in the Department of Chemistry and Biomolecular Science at Clarkson University, Potsdam, NY. Her research expertise is in analytical and bioanalytical chemistry focusing on the development, characterization and application of chemical and biological sensors for clinical, food and environmental monitoring. She published more than 55 peer-reviewed journal articles and 11 book chapters, and delivered some 100 presentations at professional and academic conferences

Hepel, Maria
Maria Hepel received the M.S. and Ph.D. degrees in chemistry from Jagellonian University in Krakow, Poland. From 1985 she worked as the Faculty at the State University of New York at Potsdam where she is now a Professor and Chair of the Department of Chemistry. She published over 140 papers, 25 chapters in books, and has made over 400 presentations at the national and international symposia. She organized many symposia at the American Chemical Society, Electrochemical Society andInternational Society of Electrochemistry Meetings and has been the program chair of the 2010 North-East Regional Meeting of ACS

Silvana Andreescu is Associate professor in the Department of Chemistry and Biomolecular Science at Clarkson University, Potsdam, NY. Her research expertise is in analytical and bioanalytical chemistry focusing on the development, characterization and application of chemical and biological sensors for clinical, food and environmental monitoring. She published more than 55 peer-reviewed journal articles and 11 book chapters, and delivered some 100 presentations at professional and academic
conferences.

Maria Hepel received the M.S. and Ph.D. degrees in chemistry from Jagellonian University in Krakow, Poland. From 1985 she worked as the Faculty at the State University of New York at Potsdam where she is now a Professor and Chair of the Department of Chemistry. She published over 140 papers, 25 chapters in books, and has made over 400 presentations at the national and international symposia.