Good Research Practice in Non-Clinical Pharmacology and Biomedicine

1. Auflage 2020
ISBN: 978-3-030-33658-5
Verlag: Springer International Publishing

Buch, Englisch, Band 257, 423 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 657 g

Reihe: Handbook of Experimental Pharmacology

This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

Zielgruppe

Research

Autoren/Hrsg.

Bespalov, Anton

Steckler, Thomas

Michel, Martin C.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Kardiologie, Angiologie, Phlebologie

Inhaltsverzeichnis

1. Quality in Non-GxP Research Environment.- 2. Guidelines & Initiatives for Good Research Practice.- 3. Learning from principles of evidence-based medicine to optimize nonclinical research practices.- 4. General Principles of Preclinical Study Design.- 5. Resolving the tension between exploration and confirmation in preclinical biomedical research.- 6. Blinding and Randomization.- 7. Out of control? Managing baseline variability in experimental studies with control groups.- 8. Quality of Research Tools.- 9. Genetic background and sex: impact on generalizability of research findings in pharmacology studies.- 10. Building robustness intro translational research.- 11. Minimum information and quality standards for conducting, reporting, and organizing in vitro research.- 12. Minimum Information in In Vivo Research.- 13. A reckless guide to P-values: Local evidence, global errors.- 14. Electronic Lab Notebooks and Experimental Design Assistants.- 15. Data storage.- 16. Design of meta-analysis studies.- 17. Publishers’ responsibilities in promoting data quality and reproducibility.- 18. Quality governance in biomedical research.- 19. Good Research Practice – Lessons from Animal Care & Use.- 20. Research collaborations and quality in research: foes or friends?.- 21. Costs of implementing quality in research practice.