Advances in Eicosanoid Research

2000
ISBN: 978-3-540-66747-6
Verlag: Springer

Buch, Englisch, Band 31, 225 Seiten, Gewicht: 440 g

Reihe: Ernst Schering Foundation Symposium Proceedings

Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. Receptor an­ tagonists for leukotrienes have been tested as anti-inflammatories and are on the market as a treatment for asthma. Receptor agonists for pro­ stacyclin are being tested for the treatment of peripheral vascular dis­ ease, and selective inhibitors of cyclooxygenase type II were just ap­ proved for the treatment of rheumatoid arthritis. All these developments are the culmination of many years and man-hours of careful research. The field has now entered an upswing that will result in novel thera­ peutic applications within the next 10 years. New molecules and me­ diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged. The concept of ei­ cosanoids as "pro-inflammatory" molecules is being challenged, and their role as regulators is increasingly recognized. In fact, some of these molecules may be important endogenous anti-inflammatory agents.

Zielgruppe

Research

Autoren/Hrsg.

Serhan, C.N.

Perez, H.D.

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Industrielle Biotechnologie
• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Biowissenschaften Lipidologie
• Interdisziplinäres Wissenschaften Wissenschaften: Forschung und Information Forschungsmethodik, Wissenschaftliche Ausstattung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Enzymologie

Inhaltsverzeichnis

1 The Mechanism of Action of Anti-Inflammatory Drugs.- 2 Human Group-V Phospholipase-A2 Expression in Pichia pastoris and Its Role in Eicosanoid Generation.- 3 Fatty-Acid Substrate Interactions with Cyclooxygenases.- 4 Structure, Function and Inhibition of Cyclooxygenases.- 5 Leukotriene-A4 Hydrolase: Probing the Active Sites and Catalytic Mechanisms by Site-Directed Mutagenesis.- 6 The Regulation of Cyclooxygenase-1 and -2 in Knockout Cells and Cyclooxygenase and Fever in Knockout Mice.- 7 Leukotriene-B4 Receptor and Signal Transduction.- 8 Lipoxins, Aspirin-Triggered 15-epi-Lipoxin Stable Analogs and Their Receptors in Anti-Inflammation: a Window for Therapeutic Opportunity.- 9 Lipoxin-Stable Analogs: Potential Therapeutic Downregulators of Intestinal Inflammation.- 10 The Role of Eicosanoids in Tumor Growth and Metastasis.- Previous Volumes Published in this Series.