Itisabundantlyclearthattheendocannabinoidsignallingsystemisubiquitously expressedthroughouttheanimalkingdomfromsimpleinvertebratestoman,and thatitisrepresentedinalmosteverycelltype. Thecomponentsofthesysteminrelationtothesynthesisandmetabolismofthe endocannabinoidsandtheirbiologicaltargetsarebeginningtobeunravelled,but the degree of complexity involved is enormous. This is particularly true for endocannabinoidsignallinginthecentralnervoussystem,whichisthesubjectof thisvolume. Inthebook,avarietyofauthors,whoareallveryactiveresearchersinthe?eld, providecurrentaccountsoftherolesoftheendocannabinoidsysteminnormalbrain physiologyinrelationtotheneurobiologyofessentialbehaviorsandinanumberof centraldiseasestates. The?rstpartprovidesabackgroundand“toolbox”,detailingwhatisknown abouttheendocannabinoidsthemselvesandtheirtargetreceptorsandhowthey in?uencesynapticactivity. Itgoesontodescribethegeneticandpharmacological methodsavailableforinvestigatingthesystem. The second part describes endocannabinoid roles in key systems controlling appetite,pain,memoryandlearning,stressresponsesandreproduction. The?nalgroupofchaptersreviewsthecurrentstateofknowledgesurrounding thefunctionoftheendocannabinoidsystemindepression,drugaddiction,schi- phrenia,feedingdisordersandTourette’ssyndrome. Giventheenormousamountofinformationavailableandtherateofprogressin research,itisimpossibleforthevolumetobetotallycomprehensive,butwetrust thatitwillprovideanexcellentbackgroundtoresearcherswantingtoexpandtheir areaofinterestandtonewcomerstothe?eld. Nottingham,UnitedKingdom DavidKendall StephenAlexander v Contents PartI Biochemistry,Pharmacology,GeneticsandChemistry 1 TheLifeCycleoftheEndocannabinoids:Formation andInactivation. 3 StephenP. H. AlexanderandDavidA. Kendall 2 EndocannabinoidReceptorPharmacology. 37 KenMackieandBettyYao 3 EndocannabinoidReceptors:CNSLocalizationoftheCB 1 CannabinoidReceptor. 65 Istva´nKatona 4 PharmacologicalToolsinEndocannabinoidNeurobiology. 87 MarcoMorandAlessioLodola 5 GeneticModelsoftheEndocannabinoidSystem. 111 KrisztinaMonoryandBeatLutz 6 EndocannabinoidSignalinginNeuralPlasticity. 141 BradleyE. Alger 7 LessonsfromNonmammalianSpecies. 173 KenSoderstrom PartII PhysiologyandPathophysiology 8 RolesoftheEndocannabinoidSysteminLearning andMemory. 201 ˆ GiovanniMarsicanoandPaulineLafenetre vii viii Contents 9 EndocannabinoidsandtheNon-HomeostaticControl ofAppetite. 231 TimC. Kirkham 10 Cannabinoid/EndocannabinoidSignalingImpactonEarly PregnancyEvents. 255 XiaofeiSunandSudhansuK. Dey 11 TargetingtheCannabinoidSystemtoProduceAnalgesia. 275 DeviRaniSagar,MaulikJhaveri,andVictoriaChapman 12 IntegrationofEndocannabinoidSignalingintotheNeural NetworkRegulatingStress-InducedActivationofthe Hypothalamic–Pituitary–AdrenalAxis. 289 BorisB. GorzalkaandMatthewN. Hill PartIII Pathology 13 DrugAddiction. 309 ZuzanaJustinova,LeighV. Panlilio,andStevenR. Goldberg 14 RoleofEndocannabinoidSignalinginAnxietyandDepression. 347 SachinPatelandCeciliaJ. Hillard 15 FeedingDisordersandObesity. 373 CristinaCervino,ValentinaVicennati,RenatoPasquali, andUbertoPagotto 16 Schizophrenia. 387 F. Markus 17 Tourette’sSyndrome. 397 KirstenR. Müller-Vahl Index. 411 Contributors StephenP. H. Alexander SchoolofBiomedicalSciencesandInstituteofNeuroscience,UniversityofN- tingham Medical School, Queens Medical Centre, Nottingham NG7 2UH, UK; steve. alexander@nottingham. ac. uk BradleyE. Alger Departments of Physiology and Psychiatry, University of Maryland School of Medicine, 655 W. Baltimore St. /BRB 5-025, Baltimore, MD 21201, USA; balger@umaryland. edu CristinaCervino Endocrinology Unit and Center of Applied Biomedical Research (C. R. B. A. ), DepartmentofInternalMedicineandGastroenterology,S. Orsola-MalpighiHos- tal,AlmaMaterStudiorumUniversityofBologna,40138Bologna,Italy VictoriaChapman SchoolofBiomedicalSciences,UniversityofNottingham,NottinghamNG72UH, UK;victoria. chapman@nottingham. ac. uk SudhansuK. Dey Departments of Pharmacology, Pediatrics and Cell & Developmental Biology, Division of Reproductive and Developmental Biology, Vanderbilt University MedicalCenter,Nashville,TN37232,USA;sk. dey@vanderbilt. edu StevenR.
Alexander / Kendall
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Weitere Infos & Material
Biochemistry, Pharmacology, Genetics & Chemistry.- The Life Cycle of the Endocannabinoids: Formation and Inactivation.- Endocannabinoid Receptor Pharmacology.- Endocannabinoid Receptors: CNS Localization of the CB1 Cannabinoid Receptor.- Pharmacological Tools in Endocannabinoid Neurobiology.- Genetic Models of the Endocannabinoid System.- Endocannabinoid Signaling in Neural Plasticity.- Lessons from Nonmammalian Species.- Physiology and Pathophysiology.- Roles of the Endocannabinoid System in Learning and Memory.- Endocannabinoids and the Non-Homeostatic Control of Appetite.- Cannabinoid/Endocannabinoid Signaling Impact on Early Pregnancy Events.- Targeting the Cannabinoid System to Produce Analgesia.- Integration of Endocannabinoid Signaling into the Neural Network Regulating Stress-Induced Activation of the Hypothalamic–Pituitary–Adrenal Axis.- Pathology.- Drug Addiction.- Role of Endocannabinoid Signaling in Anxiety and Depression.- Feeding Disorders and Obesity.- Schizophrenia.- Tourette’s Syndrome.
