Pathobiochemistry and Clinical Management
Buch, Englisch, 301 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 487 g
ISBN: 978-3-540-57239-8
Verlag: Springer Berlin Heidelberg
renowned clinicians and basic researchers discuss the
present state of knowledge of the etiologyand pathogenesis
of Dupuytren's contracture, a disease responsible for a
considerable portion of disabilities within the working
population allover the world. Although the riddle of how
the contracture of the palmar fascia develops is still
unsolved, the data on the pathobiochemistry and clinic of
Dupuytren's Disease achieved in recent years has led to a
better understanding of the biochemical and morphological
processes underlying the deformation and malfunction of the
afflicted tissues. Research in Dupuytren's Disease now
enters the era of molecular medicine, which opens up new
experimental means of studying the pathological changes
which occur during the formation of the contracture on a
molecular level. In particular, data are presented as to the
role of specific biological macromolecules influencing the
phenotype expression of the palmar fascia cells which are
involved in autoimmune reactions and present both at the
cell surface as well as in the extracellular matrix to
regulate cell-to-cell and cell-to-matrix interactions. In
vitro cell culture models to investigate fibro-cytic
modulations are available and havebeen applied to study the
effects of specific biological molecules on isolated cells
from healthy palmar fascia and Dupuytren's contracture.
Complementary evaluations of morphological, epidemiological,
and clinical data contribute essentially to the present
understanding of the etiology and pathogenesis of
Dupuytren's Disease. This comprehensive and informative
summary of the state of the art is completed by numerous
references affixed to the individual contributions.
Zielgruppe
Professional/practitioner
Autoren/Hrsg.
Weitere Infos & Material
Morphology.- Morphology of Dupuytren’s Disease.- Interactions Between Proteoglycans and Collagen Fibrils in the Palmar Fascia in Dupuytren’s Disease.- Myofibroblasts Are Not Specific to Dupuytren’s Disease.- The Significance of Skin Anchoring Fibres in Palmar Fibrosis: Brief Comment.- Pathobiochemistry of Fibrillar Component.- Collagen Changes in Dupuytren’s Disease.- Connective Tissue Autoantibodies in Dupuytren’s Disease: Associations with HLA DR3.- Collagen Production by Cultured Dupuytren’s Fibroblasts.- Proteoglycans and Glycosaminoglycans.- Proteoglycans in Biopsies of Dupuytren’s Contracture.- Glycosaminoglycan Distribution Pattern in Dupuytren’s Contracture Biopsies.- Biochemical Parameters for the Diagnosis of Dupuytren’s Disease.- Pathobiochemistry of Cells in Dupuytren’s Contracture.- Investigations of Cell Cultures Derived from Patients Suffering from Dupuytren’s Contracture.- Fibroblast Gel Culture: A Model for Biochemical Investigations of Dupuytren’s Contracture.- Reactivity of Cells in Nodules of Dupuytren’s Contracture with Monoclonal Antibodies Recognizing Leukocyte Antigens and von Willebrand’s Factor.- Demonstration of Myofibroblasts Using a Novel Murine Monoclonal Antibody, 3C2G10.7 Raised from Proliferating Cells in Dupuytren’s Disease.- Reactivity of Nodular Cells in Vitro: A Guide to the Pharmacological Treatment of Dupuytren’s Contracture.- Extracellular Matrix Components and Macromolecular Interactions.- Stromal-Epithelial Cell Interactions in the Mechanisms of Hepatocyte Injury, Liver Cell Regeneration and Fibrogenesis.- Proteoglycan — Collagen Fibril Interactions in Tissues.- Changes in the Biomechanical Properties of Diseased Tissue as Pathogenetic Factors in Dupuytren’s Contracture.- Fibromatoses.- Localization and Morphology of Different Fibromatoses.- Thermal Stability and Fibrillogenesis of Collagen from Tissue of Patients with Dupuytren’s Disease.- Macrophage Activity, Fibronectin, and SPARC Protein in Experimentally Induced Granuloma.- Modulation of Fibroblastic Cytoskeletal Features During Dupuytren’s Disease.- Oxygen Free Radicals and Dupuytren’s Disease.- Clinical Findings and Epidemiology of Dupuytren’s Disease.- Clinical Findings in Dupuytren’s Disease.- Epidemiology of Dupuytren’s Disease.- Clinical Management of Dupuytren’s Disease.- Limited Fasciectomy.- Fasciotomy and the Open Palm Technique.- Skin Grafting in the Management of Dupuytren’s Disease.- Recurrence in Dupuytren’s Disease.- Refinements of Plastic Surgery in Relapsing Dupuytren’s Disease: Incisions, Flaps, Treatment of Perfusion Disorders, Physiotherapy, and Splinting.- The Complications and Unsatisfactory Results of Treatment for Dupuytren’s Disease.- The Continuous Elongation Technique in Dupuytren’s Disease.
