TRP Channels in Drug Discovery

Volume I
2012
ISBN: 978-1-62703-076-2
Verlag: Humana Press

Buch, Englisch, 446 Seiten, HC gerader Rücken kaschiert, Format (B × H): 183 mm x 260 mm, Gewicht: 1056 g

Reihe: Methods in Pharmacology and Toxicology

Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention.  TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field.  Volume I presents a series of state-of-the-art minireviews on the most interesting TRP channels (from TRPA1 to TRPV4), as well as TRP-related protocols involving airways and the genitourinary tract.  Written for the Methods in Pharmacology and Toxicology™ series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab.
 
Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Bíró, Tamás

Szallasi, Arpad

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie

Inhaltsverzeichnis

Part I: Introduction
 
1. Introduction to TRPs: A Quest for Novel Drug Targets
            Bernd Nilius
 
2. TRP-Mediated Cytoskeletal Reorganization: Implications for Disease and Drug Development
            Chandan Goswami
 
Part II: TRP Channels, from A1 to V4
 
3. TRPA1 in Drug Discovery
            Jun Chen, Steve McGaraughty, and Philip R. Kym
 
4. Canonical Transient Receptor Potential Channel (TRPC) Expression, Regulation, and Function in Vascular and Airway Diseases
            Brij B. Singh, Christina M. Pabelick, and Y.S. Prakash
 
5. TRPM2 Function and Potential as a Drug Target
            Barbara A. Miller
 
6. The Ca2+-Activated Monovalent Cation Selective Channels TRPM4 and TRPM5
            Colsoul Barbara, Kecskes Miklos, Philippaert Koenraad, Menigoz Aurelie, and Vennekens Rudi
 
7. The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis
            Vladimir Chubanov, Jonathan T. Eggenschwiler, Thomas Gudermann, and Alexey G. Ryazanov
 
8. TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation
            David D. McKemy
 
9. TRPML Channels in Function, Disease, and Prospective Therapies
            David A. Zeevi
 
10. The TRPP Signalling Module: TRPP2/Polycystin 1 and TRPP2/PKD1L1            Alexis Hofherr
 
11. TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities            Olivier Radresa, Stephen Zicha, William Brown, and Jennifer M.A. Laird
 
12. Nociceptive and Non-Nociceptive Roles of TRPV3 and Its “Druggability”            Sungjae Yoo and Sun Wook Hwang
 
13. TRPV4 and Drug Discovery            Fabien Vincent and Matthew A.J.  Duncton
 
Part III: TRPs and Airways
 
14. TRP Expression and Function in the Lung Airways
            Alexander Dietrich and Thomas Gudermann
 
15. Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells
            Beate Fuchs, Hermann Kalwa, Norbert Weissmann, Thomas Gudermann, and Alexander Dietrich
 
16. Endotoxin-Induced Airway Inflammation and Asthma Models
            Zsuzsanna Helyes and Zsófia Hajna
 
17. Enhanced Cough, Animal Models            Raffaele Gatti, Pamela Pedretti, Romina Nassini, and Marcello Trevisani
 
18. Capsaicin Inhalation Test in Man            Eva Millqvist
 
Part IV: TRPs and the Genitourinary (GU) Tract 
19. TRP Channels in the Genitourinary (GU) Tract            Ana Charrua and Francisco Cruz
 
20. Animal Models of Cystitis
            Célia D. Cruz and António Avelino
 
21. Overactive Bladder Models            Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson

            Alexis Hofherr
 
11. TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities            Olivier Radresa, Stephen Zicha, William Brown, and Jennifer M.A. Laird
 
12. Nociceptive and Non-Nociceptive Roles of TRPV3 and Its “Druggability”            Sungjae Yoo and Sun Wook Hwang
 
13. TRPV4 and Drug Discovery            Fabien Vincent and Matthew A.J.  Duncton
 
Part III: TRPs and Airways
 
14. TRP Expression and Function in the Lung Airways
            Alexander Dietrich and Thomas Gudermann
 
15. Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells
            Beate Fuchs, Hermann Kalwa, Norbert Weissmann, Thomas Gudermann, and Alexander Dietrich
 
16. Endotoxin-Induced Airway Inflammation and Asthma Models
            Zsuzsanna Helyes and Zsófia Hajna
 
17. Enhanced Cough, Animal Models            Raffaele Gatti, Pamela Pedretti, Romina Nassini, and Marcello Trevisani
 
18. Capsaicin Inhalation Test in Man            Eva Millqvist
 
Part IV: TRPs and the Genitourinary (GU) Tract 
19. TRP Channels in the Genitourinary (GU) Tract            Ana Charrua and Francisco Cruz
 
20. Animal Models of Cystitis
            Célia D. Cruz and Antó