Asymmetric Synthesis with Chemical and Biological Methods

1. Auflage 2007
ISBN: 978-3-527-31473-7
Verlag: Wiley-VCH

Buch, Englisch, 446 Seiten, Format (B × H): 177 mm x 246 mm, Gewicht: 1028 g

Edited by two of the leading researchers in the field, this book provides a deep, interdisciplinary insight into stoichiometric and catalytic reactions in this continuously expanding area. A plethora of top German scientists with an international reputation covers various aspects, from classical organic chemistry to process development, and from the theoretical background to biological methods using enzymes. Throughout the focus is on the development of new synthetic methods in asymmetric synthesis, the synthesis of natural and bioactive compounds and the latest developments in both chemical and biological methods of catalysis, as well as the investigation of special technical and biotechnical aspects.

Autoren/Hrsg.

Enders, Dieter

Jaeger, Karl-Erich

Weitere Mitwirkende

Helmchen, Günter

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie Supramolekularchemie
• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Chemie Organische Chemie Organometallchemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Industrielle Biotechnologie

Inhaltsverzeichnis

STOICHIOMETRIC ASYMMETRIC SYNTHESISDevelopment of Novel Enantioselective Synthetic MethodsAsymmetric Synthesis of Natural Products Employing the SAMP/RAMP-Hydrazone MethodologyAsymmetric Synthesis Based on Sulfonimidoyl-Substituted Allyltitanium ComplexesThe "Daniphos" Ligands: Synthesis and Catalytic ApplicationsNew Chiral Ligands Based on Substituted HeterometallocenesCATALYTIC ASYMMETRIC SYNTHESIS WITH CHEMICAL METHODSSulfoximines as Ligands in Asymmetric Metal CatalysisCatalyzed Asymmetric Aryl Transfer ReactionsSubstituted [2.2]-Paracyclophane Derivatives as Efficient Ligands for Asymmetric 1,2- and 1,4-Addition ReactionsPalladium-Catalyzed Allylic Alkylation of Sulfur and Oxygen Nucleophiles - Asymmetric Synthesis, Kinetic Resolution and Dynamic Kinetic ResolutionThe QUINAPHOS Ligand Family and its Application in Asymmetric SynthesisImmobilization of Transition Metal Complexes and their Application to Enantioselective CatalysisCATALYTIC ASYMMETRIC SYNTHESIS WITH BIOLOGICAL METHODSDirected Evolution to Increase the Substrate Range of Benzoylformate Decarboxylase from Pseudomonas PutidaC-C Bonding Microbial Enzymes: Thiamine Diphosphate-Dependent Enzymes and Class I AldolasesEnzymes for Carboligation - 2-Ketoacid Decarboxylases and Hydroxynitrile LyasesPreparative Syntheses of Chiral Alcohols using (R)-specific Alcohol Dehydrogenases from Lactobacillus strainsBiocatalytic C-C Bond Formation in Asymmetric SynthesisExploring and Broadening the Biocatalytic Properties of Recombinant Sucrose Synthase 1 for the Synthesis of Sucrose AnaloguesFlexible Asymmetric Redox Reactions and C-C Bond Formation by Bioorganic Synthetic StrategiesREACTION TECHNOLOGY IN ASYMMETRIC SYNTHESISReaction Engineering in Asymmetric SynthesisBiocatalyzed Asymmetric Syntheses Using Gel-Stabilized Aqueous-Organic Two-Phase Systems

STOICHIOMETRIC ASYMMETRIC SYNTHESISDevelopment of Novel Enantioselective Synthetic MethodsAsymmetric Synthesis of Natural Products Employing the SAMP/RAMP-Hydrazone MethodologyAsymmetric Synthesis Based on Sulfonimidoyl-Substituted Allyltitanium ComplexesThe "Daniphos" Ligands: Synthesis and Catalytic ApplicationsNew Chiral Ligands Based on Substituted HeterometallocenesCATALYTIC ASYMMETRIC SYNTHESIS WITH CHEMICAL METHODSSulfoximines as Ligands in Asymmetric Metal CatalysisCatalyzed Asymmetric Aryl Transfer ReactionsSubstituted [2.2]-Paracyclophane Derivatives as Efficient Ligands for Asymmetric 1,2- and 1,4-Addition ReactionsPalladium-Catalyzed Allylic Alkylation of Sulfur and Oxygen Nucleophiles - Asymmetric Synthesis, Kinetic Resolution and Dynamic Kinetic ResolutionThe QUINAPHOS Ligand Family and its Application in Asymmetric SynthesisImmobilization of Transition Metal Complexes and their Application to Enantioselective CatalysisCATALYTIC ASYMMETRIC SYNTHESIS WITH BIOLOGICAL METHODSDirected Evolution to Increase the Substrate Range of Benzoylformate Decarboxylase from Pseudomonas PutidaC-C Bonding Microbial Enzymes: Thiamine Diphosphate-Dependent Enzymes and Class I AldolasesEnzymes for Carboligation - 2-Ketoacid Decarboxylases and Hydroxynitrile LyasesPreparative Syntheses of Chiral Alcohols using (R)-specific Alcohol Dehydrogenases from Lactobacillus strainsBiocatalytic C-C Bond Formation in Asymmetric SynthesisExploring and Broadening the Biocatalytic Properties of Recombinant Sucrose Synthase 1 for the Synthesis of Sucrose AnaloguesFlexible Asymmetric Redox Reactions and C-C Bond Formation by Bioorganic Synthetic StrategiesREACTION TECHNOLOGY IN ASYMMETRIC SYNTHESISReaction Engineering in Asymmetric SynthesisBiocatalyzed Asymmetric Syntheses Using Gel-Stabilized Aqueous-Organic Two-Phase Systems

Über Autor(innen)

Dieter Enders completed his PhD at the Justus-Liebig-Universität Giessen under the supervision of D. Seebach. After postdoctoral studies at Harvard University with E. J. Corey, he returned to Giessen and completed his habilitation. He became Associate Professor at the Universität Bonn in 1980, and moved to his present position as Professor of Organic Chemistry at the RWTH Aachen in 1985. He has received many awards (Leibniz-Prize of the DFG, Emil Fischer Medal of the GDCh, Yamada Prize, Japan) for his research, which focuses on the asymmetric synthesis of biologically active compounds and the development of new synthetic methods.Karl-Erich Jaeger was born in Dortmund and studied biology and chemistry at the Ruhr-University Bochum, where he received his PhD under the supervision of U. Winkler. After postdoctoral studies with Robert E.W. Hancock at the Department of Microbiology of the University of British Columbia in Vancouver, he received his habilitation in Bochum in 1995. Karl-Erich Jaeger is currently Professor at the Heinrich-Heine University of Düsseldorf and Director of the Institute of Molecular Enzyme Technology at the Research Centre Jülich. His research interests include the expression, folding and secretion of bacterial enzymes, their optimization by directed evolution, and enantioselective biocatalysis.