Buch, Englisch, 308 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 810 g
Volume 12
Buch, Englisch, 308 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 810 g
ISBN: 978-0-12-821310-0
Verlag: Elsevier Science
Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges.
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
1. Introductory Chapter2. Tumor Metabolic Reprogramming in Therapeutic Resistance3. Development of novel antiandrogens to overcome castrate resistant prostate cancer4. Microenvironmental regulation of cancer response to therapy and therapy resistance5. Revisiting immunogenic cell death to overcome treatment resistance in cancer immunotherapy6. Preventing Phenotypic Plasticity in Cancer to Mitigate Therapy Resistance7. Overcoming drug resistance in cancer with targeted radionuclide therapy8. The PI3K pathway and chemotherapy resistance9. Targeting leukemia stem cells in T-cell acute lymphoblastic leukemia10. Escape from apoptosis: Anastasis as a potential mechanism of cancer drug resistance11. From genetic data and structures to drug development: new approaches to targeting Eph receptors12. Overcoming Therapeutic Resistance in Glioblastoma: a major clinical challenge