Buch, Englisch, 474 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 995 g
Buch, Englisch, 474 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 995 g
Reihe: Statistics for Biology and Health
ISBN: 978-0-387-25146-2
Verlag: Springer
This volume's coverage is broad and ranges across most of the key capabilities of the Bioconductor project, including importation and preprocessing of high-throughput data from microarray, proteomic, and flow cytometry platforms:
Curation and delivery of biological metadata for use in statistical modeling and interpretation
Statistical analysis of high-throughput data, including machine learning and visualization
Modeling and visualization of graphs and networks
The developers of the software, who are in many cases leading academic researchers, jointly authored chapters. All methods are illustrated with publicly available data, and a major section of the book is devoted to exposition of fully worked case studies.
This book is more than a static collection of descriptive text, figures, and code examples that were run by the authors to produce the text; it is a dynamic document. Code underlying all of the computations that are shown is made available on a companion website, and readers can reproduce every number, figure, and table on their own computers.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
- Interdisziplinäres Wissenschaften Wissenschaften: Forschung und Information Datenanalyse, Datenverarbeitung
- Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tiergenetik, Reproduktion
- Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
Weitere Infos & Material
Preprocessing data from genomic experiments.- Preprocessing Overview.- Preprocessing High-density Oligonucleotide Arrays.- Quality Assessment of Affymetrix GeneChip Data.- Preprocessing Two-Color Spotted Arrays.- Cell-Based Assays.- SELDI-TOF Mass Spectrometry Protein Data.- Meta-data: biological annotation and visualization.- Meta-data Resources and Tools in Bioconductor.- Querying On-line Resources.- Interactive Outputs.- Visualizing Data.- Statistical analysis for genomic experiments.- Analysis Overview.- Distance Measures in DNA Microarray Data Analysis.- Cluster Analysis of Genomic Data.- Analysis of Differential Gene Expression Studies.- Multiple Testing Procedures: the multtest Package and Applications to Genomics.- Machine Learning Concepts and Tools for Statistical Genomics.- Ensemble Methods of Computational Inference.- Browser-based Affymetrix Analysis and Annotation.- Graphs and networks.- and Motivating Examples.- Graphs.- Bioconductor Software for Graphs.- Case Studies Using Graphs on Biological Data.- Case studies.- limma: Linear Models for Microarray Data.- Classification with Gene Expression Data.- From CEL Files to Annotated Lists of Interesting Genes.