ICRP Publication 99

Low-Dose Extrapolation of Radiation-related Cancer Risk
1. Auflage 2006
ISBN: 978-0-08-044958-6
Verlag: SAGE Publications Ltd

Buch, Englisch, 150 Seiten, HC gerader Rücken kaschiert, Format (B × H): 175 mm x 250 mm, Gewicht: 452 g

Reihe: Annals of the ICRP

This report considers the evidence relating to cancer risk associated with exposure to low doses of low linear energy transfer radiation, and particularly doses below current recommended limits for protection of radiation workers and the general public. The focus is on evidence regarding linearity of the dose–response relationship for all cancers considered as a group, but not necessarily individually, at low doses [the so-called linear, non-threshold (LNT) hypothesis]. It looks at the possibility of establishing a universal threshold dose below which there is no risk of radiation-related cancer. The report is organised by scientific discipline, beginning with epidemiological studies of exposed human populations.

Autoren/Hrsg.

ICRP,

Icrp

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Präventivmedizin, Gesundheitsförderung, Medizinisches Screening
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Public Health, Gesundheitsmanagement, Gesundheitsökonomie, Gesundheitspolitik

Inhaltsverzeichnis

ABSTRACT

GUEST EDITORIAL

PREFACE

EXECUTIVE SUMMARY

INTRODUCTION

EPIDEMIOLOGICAL CONSIDERATION

Introduction

Inferences based on acute doses in the moderate-to-high dose range

Estimation of risk at low doses and low dose rates

Thresholds vs. the linear, no-threshold theory

Conclusion: Implications for low-dose cancer risk

LOW-DOSE RISK - BIOLOGY

Introduction

Damage caused by radiation

Damage Response Pathways

Fidelity of DSB repair

Impact of defects in DNA repair, checkpoint control and apoptosis

Conclusions

CELLULAR CONSEQUENCES OF RADIATION-INDUCED DAMAGE

Radiation- induced Chromosome Aberrations

Radiation-Induced Somatic Cell Mutations

Adaptive Response, Genomic Instability and Bystander Effect

Conclusions: Implications for Risk Assessment

CARCINOGENIC EFFECTS OF IONIZING RADIATION

Mechanisms of radiation-induced cancer

Tissue Modifying Factors

Radiation-induced Cancer in Animals

Life Shortening

Summary

Conclusions: Implications for radiation-related cancer at low doses

QUANTITATIVE UNCERTAINTY ANALYSIS

Overview

Sources of uncertainty

Allowing for the uncertain possibility of a threshold

Conclusions

CONCLUSIONS

REFERENCES