Molecular Pharming

Applications, Challenges, and Emerging Areas
1. Auflage 2018
ISBN: 978-1-118-80128-4
Verlag: Wiley

Buch, Englisch, 496 Seiten, Format (B × H): 173 mm x 244 mm, Gewicht: 1066 g

A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins

This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes.

Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology.
* Broad ranging coverage of a key area of plant biotechnology
* Describes efforts to produce pharmaceutical and industrial proteins in plants
* Provides reviews of recent advances and technology breakthroughs
* Assesses realities of regulatory and cost hurdles
* Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes

Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.

Autoren/Hrsg.

Kermode, Allison R

Jiang, Liwen

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

I. Technologies and Challenges

1. Overview of PMPs (platforms, applications, challenges, regulatory issues, exciting emerging areas) Allison R. Kermode & Carole Cramer
2. Gene tinkering and other tools for high-level yields of PMPs in plant and seed expression systems (E. Stoger, SJ Streatfield)
3. Production of functionally active recombinant proteins in plants: Manipulating N-glycosylation (R. Strasser)
4. Emerging technologies for precise N-glycan analyses (Carolyn Bertozzi & Mark Breidenback)

5. Manipulation of O-glycosylation & other PTMs in plants (L. Faye & Gomord)

6. Enhancement of protein yields to facilitate downstream processing of recombinant proteins (M. Torrent, R. Menassa)

7. Recovery and purification of plant-made recombinant proteins (Wilken LR & Nikolov, ZL; Texas A & M)

8. Quality assessment of bioproducts (C. Cramer)

II. Applications of Molecular Pharming
9. Recombinant antibodies (Herta Steinkellner, Chris Hall)

10. Vaccines (W.H. Langridge)

11. Therapeutic enzymes for metabolic diseases (A. Kermode)

12. Industrial and medicinal enzymes (TBA) M. Mizutani (Japan) or Yonghua Li (France)

III. Issues and Cost Evaluation

13. Assessing biosafety; containment and other issues (S.V. Reddy)

14. Bioprocess design & cost analyses: Comparison of eukaryotic production platforms (Kay McDonald, UC Davis)

IV. Emerging areas

15. An Update: The impact of Arabidopsis on Human Health: Diversifying Our Portfolio. Alan M. Jones, Joanne Chory, Jeffery L. Dangl, Estelle M., Jacobsen, S.E., Meyerowitz, E.M., Magnus Nordborg and Detlef Weigel

16. Plant-Pathogen interactions: toward the creation of novel drugs (M. Kaiser) or:Plant innate immunity: Toward identifying novel drugs for infectious diseases (Eric Lam)

17. Identification of small molecule therapeutics for protein conformational diseases (Allison R. Kermode and John Littleton)

18. Manipulation of plant secondary metabolites (Peter Facchini)

19. Trichome libraries: New collections of bioactive molecules (Robert Last)

20. Multi-component drug design: Medicinal herbs and traditional Chinese medicine (Y. Cheng; Zhejiang University)

21. Plants as models for human cancers (G. Wastaneys)

22. Mammalian inducible gene expression systems based on exploitation of plant hormone signal transduction networks (Sean Cutler)

23. Development of small molecule libraries: The future of plant drug discovery (Freeman Chow and Sean Cutler)

24. Plant small molecules and dynamic endomembrane networks in vivo: basic and applied research (G.Hicks & N. Raikhel)

Über Autor(innen)

Allison R. Kermode is Professor and Michael Smith Senior Scholar at Simon Fraser University. Her work on plant-derived human proteins was recently featured in Nature magazine. Dr. Kermode is also the editor of Seed Dormancy: Methods and Protocols.

Liwen Jiang is Choh-Ming Li Professor of Life Sciences at the Chinese University of Hong Kong. He is a leader in research on protein targeting and trafficking in plant cells, plant organelle biogenesis and function, and the application of these processes to plant biotechnology.