Buch, Englisch, 416 Seiten, Format (B × H): 168 mm x 244 mm, Gewicht: 907 g
An Integrated Approach
Buch, Englisch, 416 Seiten, Format (B × H): 168 mm x 244 mm, Gewicht: 907 g
ISBN: 978-0-470-84431-1
Verlag: Wiley
Taking a modern approach to the subject, the text opens with a discussion on the history of neuroendocrinology and the structure of early neuroendocrine systems in primitive animals. The evolution of ancestral neuroendocrine systems is then traced to living species. With this background in place, the physiology of the neuroendocrine circuits regulating metabolism, biorhythms, stress and reproduction across the animal kingdom are examined. The book ends with chapters on how the neuroendocrine system is regulated by pheromones and xenobiotics in the environment.
This book is an invaluable reference for students taking courses in Neuroendocrinology and Endocrinology as well as those who work in Genomics based drug design and biotech companies based on neurohormones.
* An integrated genes-to-environment approach.
* Includes profiles sections written by leaders in the field highlighting unusual aspects of neuroendocrine physiology
* A unique section on the actions of environmental chemicals in neuroendocrine systems of various species.
Autoren/Hrsg.
Weitere Infos & Material
Foreword
Acknowledgments
1. History of Neuroendocrinology and Neurohormones Introduction
Early history of physiology
Renaissance and the growth of western science
Scientific revolution
The 19th-century physiology and medicine
Neurosecretion and the hypothalamus-pituitary regulation
Chapter summary
2. Origin of Life and the First Signalling Molecules
Introduction
Theories of the evolution of the first cells
The first cells
The first true signalling hormones
Chapter summary
3. Rise of Metazoans and the Elaboration of Signalling Systems
Introduction
Colonialism and multicellularity
The elaboration of hormone pathways
Nervous systems and rudimentary neuroendocrine systems
Increase in genetic complexity and the rise of triploblastic organisms
Chapter summary
4. Elaboration of Neuroendocrine Systems
Introduction
Elaboration of nervous system and development of organismal complexity
Nervous and neuroendocrine systems in phylogenetically younger invertebrates
Nervous and neuroendocrine systems in the deuterostomes
Peripheral and autonomic nervous systems
Blood-brain barriers
Cerebrospinal fluid and the choroid plexus
Neurohaemal and circumventricular organs: Neurovascular interfaces
Hypothalamus-pituitary gland complex
Chapter summary
5. Neurohormones and Receptors: Structure, Function and Co-evolution
Introduction
Orthology and paralogy
Structural description of non-peptide ligands
Peptide and polypeptide signalling molecules
Structure and classes of receptors
Receptor-ligand interactions
Receptor-ligand co-evolution
Chapter summary
6. Osmoregulation, Metabolism and Energy Production
Introduction
Osmoregulation
Role of prolactin
Feeding and appetite regulation
Neural circuitry associated with feeding
Chapter summary
7. Growth and Development
Introduction
Growth and the growth hormone, prolactin, somatolactin superfamily
Metamorphosis and development
Sexual differentiation
Mechanisms of ageing
Chapter summary
8. Biological Rythms
Introduction
Origin of biological clocks
Circadian rythms
Infradian rythms
Clock circuitry in vertebrates
The role of melatonin
Chapter summary
9. Stress, Arousal and Homeostatic Challenge
Introduction
Physiology and behaviour associated with stress Components of the stress-response system.s
Corticotropin-releasing factor superfamily of peptides
Proopiomelanocortin and adrenocorticotrophic hormone
Integration of HPA/I components with other systems
Complementary neuroendocrine circuits associated with stress
Chapter summary
10. Reproduction
Introduction
Selection of sexual reproduction
Regulation of reproduction
Gonadotrophin-releasing hormone
Gonadotrophins and their regulation
Neuroendocrine regulation of the HPG axis
Pregnancy, parturition and lactation
Seasonal reproduction
Reproduction and stress
Chapter summary
11. Behaviour, Learning and Memory
Introduction
Basic behavioural circuits
Memory
Motivation: Reward and fear
Stress and the modulation of learning and behaviour
Hormonal facilitation of behaviour
Galanin modulation of neurological circuits
An integrated approach to behavioural modulation
Neurodegeneration and trauma
Chapter summary
12. Pheromones and Chemo-attractants
Introduction
Evolution of pheromones
Classification of pheromones
Pheromones in invertebrates
Pheromones in vertebrates
Physiological actions of vertebrate pheromones
Pheromones in mammals
Chapter summary
13. Xenobiotics and Hormone Mimics
Introduction
Types of xenobiotics
Vertebrate toxins and defences
Toxins and xenobiotics in invertebrates
Toxins and hormone mimics in plants
Hormone mimics from anthropogenic sources
Chapter summary
Glossary
References
Index.
