ECTO-NOX Proteins

Growth, Cancer, and Aging
2013
ISBN: 978-1-4899-8845-4
Verlag: Springer

Buch, Englisch, 508 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 785 g

This volume documents this unique family of cell surface proteins. Despite masquerading as intractable and difficult to clone and characterize, ENOX proteins have and continue to offer remarkable opportunities for research, commercial development and outside confirmation of therapeutic, diagnostic and new paradigms to help explain complex biological processes.

Zielgruppe

Research

Autoren/Hrsg.

Morré, Dorothy M.

Morré, D. James

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Biowissenschaften Proteinforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie

Inhaltsverzeichnis

Preface.   Brief history of discovery and acknowledgments

1  The ECTO-NOX protein family

2  Measurement of ECTO-NOX (ENOX) activities

3  The constitutive ENOX1 (CNOX)

4  Role in plasma membrane electron transport

5  Role in the enlargement phase of cell growth

6  Role as ultradian oscillators of the cells’ biological clock

7  Other potential functional roles of ENOX proteins

8  ENOX2 (tNOX) and cancer

9  Age-related ENOX proteins (arNOX)

10  The auxin-stimulated ENOX and auxin-stimulation of plant growth

11  Cancer therapeutic applications of ENOX2 proteins

12  Diagnostic applicastions of –ENOX2 proteins

Appendix A Epilogue: Remaining challenges
Appendix B Detailed description of 2-D gel electrophoresis western blot early detection protocol