Buch, Englisch, Band 1639, 278 Seiten, HC runder Rücken kaschiert, Format (B × H): 183 mm x 260 mm, Gewicht: 6952 g
Reihe: Methods in Molecular Biology
Methods and Protocols
Buch, Englisch, Band 1639, 278 Seiten, HC runder Rücken kaschiert, Format (B × H): 183 mm x 260 mm, Gewicht: 6952 g
Reihe: Methods in Molecular Biology
ISBN: 978-1-4939-7161-9
Verlag: Springer
Cutting-edge and authoritative, Alpha-1 Antitrypsin Deficiency: Methods and Protocols is a valuable resource for researchers, students, and clinican-scientists interested in AAT deficiency, as well as anyone working in the fields of pulmonology and hepatology.
Zielgruppe
Professional/practitioner
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Pneumologie, Atmung, Asthma
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
Weitere Infos & Material
Preface…
Table of Contents…
Contributing Authors…
1. Pathophysiology of Alpha-1 Antitrypsin Deficiency Liver Disease
JeffreyH. Teckman and Keith S. Blomenkamp
2. Pathophysiology of Alpha-1 Antitrypsin Lung Disease
Michael Kalfopoulos, Kaitlyn Wetmore, and Mai ElMallah
3. Measuring and Interpreting Serum AAT Concentration
Leslie Donato, Melissa Snyder, and Dina N. Greene
4. AAT Phenotype Identification by Isoelectric Focusing
Dina N. Greene, M.C. Elliot-Jelf, and David G. Grenache
5. Laboratory Diagnosis by Genotyping
Irene Belmonte, Luciana Montoto, and Francisco Rodríguez-Frías
6. Genotyping Protocol for the Alpha-1 Antitrypsin (PiZ) Mouse Model
Alisha M. Gruntman
7. Elastase-Induced Lung Emphysema Models in Mice
Béla Suki, Elzsébet Bartolák-Suki, and Patricia R.M. Rocco
8. Assessing Structure-Function Relations in Mice Using the Forced Oscillation Technique and Quantitative Histology
Harikrishnan Parameswaran and Béla Suki
9. Practical Methods for Assessing Emphysema Severity Based on Estimation of Linear Mean Intercept (Lm) in the Context of Animal Models of Alpha-1 Antitrypsin Deficiency
Airiel M. Davis, Kristen E. Thane, and Andrew M. Hoffman
10. Design, Cloning, and In Vitro Screening of Artificial miRNAs to Silence Alpha-1 Antitrypsin
Florie Borel and Christian Mueller
11. Methods to Identify and Characterize siRNAs Targeting Serpin A1 In Vitro and In Vivo using RNA Interference
Stuart Milstein, Kun Qian, Linying Zhang, and Alfica Sehgal
12. Knockdown of Z Mutant Alpha-1 Antitrypsin in Vivo Using Modified DNA Antisense Oligonucleotides
Mariam Aghajan, Shuling Guo, and Brett P. Monia
13. Immunohistochemistry Staining for Human Alpha-1 Antitrypsin
Dongtao A. Fu and Martha Campbell-Thompson
14. Periodic Acid-Schiff Staining with Diastase
Dongtao A. Fu