Notch Regulation of the Immune System

2012
ISBN: 978-3-642-24293-9
Verlag: Springer

Buch, Englisch, Band 360, 184 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 465 g

Reihe: Current Topics in Microbiology and Immunology

Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system.  This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia.

Zielgruppe

Research

Autoren/Hrsg.

Radtke, Freddy

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

Preface.- The Notch pathway in hematopoietic stem cells.- Notch receptor-ligand interactions during T cell development, a ligand endocytosis driven mechanism.- Notch1 and IL-7 receptor signalling in early T-cell development and leukemia.- Notch signaling during human T cell development.- Canonical and non-canonical Notch signaling in CD4+T cells.- The role of Notch in the differentiation of CD4+ T helper cells.- Notch signaling in alloreactive T cell immunity.- Notch2 and immune function.- Recent advances on Notch signaling in T-ALL.- Subject code