Buch, Englisch, 920 Seiten, Format (B × H): 178 mm x 254 mm, Gewicht: 1700 g
Buch, Englisch, 920 Seiten, Format (B × H): 178 mm x 254 mm, Gewicht: 1700 g
ISBN: 978-0-367-44628-4
Verlag: Taylor & Francis Ltd
Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening.
Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.
Zielgruppe
Professional Practice & Development
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Enzymatic/Microbial Preparation of Chiral Epoxides. Preparation of Optically Active Cyanohydrins using Hydroxynitrile Lyases. High-throughput Biocatalysis for Accelerated Drug Discovery and Development. Enhancing the Stability of Industrial Enzymes. Biocatalytic Hydroxlation Reactions. Dehydrogenases in Synthesis of Chiral Pharmaceuticals. Biocatalysis: Applications and Potentials for the Chemical Industry. Biocatalysis using Enzymes and Microorganisms. Vitamins and Related Compounds: Microbial Production. Biocatalysis in the Preparation of Homochiral Pharamaceuticals. Stereochemistry and Evoluation of Aminotransferases. Chemoenzymatic Synthesis of Chiral Intermediates. Overview of Biocatalysis in Ionic Liquids. Preparative Biotransformations. Directed Evolution and Biocatalysis: Enantioselective Production of Amino Carboxylic Acids. Design, Sequences, and Use of Mutant Haloalkane Dehalogenases. Enantioselective Biocatalysis using Lipases and Esterases. Biocatalysis: Reduction of C=N Bonds. Stereospecific Biocatalytic Epoxidation. Cytochrome P450 BM-3: Directed Evolution & Hydroxylation Reactions. Stereoselective Synthesis of Nucleoside Analogues. Microbial Baeyer-Villiger Oxidations. Developing Novel Biocatalysis for Manufacturing Optically Active Compounds. Enzymatic Asymmetric Synthesis by Decarboxylases. Enzymatic Asymmetric C-C Bond Synthesis. Chemoenzymic Synthesis of Glycophosphopeptides. Recent Advances on Bioreductions Mediated by Baker’s Yeast and Other Microorganisms. Biotransformation and Organic Chemistry. Synthesis of Optically Active Pheromones. Microbial Carboxylations in Enantioselective Synthesis. Lipases and Oxynitrilases: Useful Tools in Organic Synthesis. Enzymatic Asymmetric using Aldolases. Enzymatic Racemization and its Application to Synthetic Biotransformations. Amidases and Dehydrogenases in Asymmetric Synthesis. Biocatalysis in Organic Synthesis. Enantiopure Alcohols by Enzymatic Resolution with In-situ Racemization. Engineered Enzyme
