Buch, Englisch, 344 Seiten, Format (B × H): 178 mm x 254 mm
Buch, Englisch, 344 Seiten, Format (B × H): 178 mm x 254 mm
ISBN: 978-0-367-46887-3
Verlag: Taylor & Francis Ltd
Features:
1. Provides a basic understanding of the physiologically based pharmacokinetic modelling and its applications
2. Assists the reader in understanding product performance to allow for rapid product development and establish bioequivalence
3. Well-constructed content and added value of real examples
4. Illustrates how using available resources via modeling and simulation leads to a reduction in the costs related to drug development, which directly affects the costs to patients
Zielgruppe
Academic, Postgraduate, Professional Practice & Development, and Undergraduate Advanced
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
- Naturwissenschaften Chemie Chemie Allgemein
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
Weitere Infos & Material
1. From A Mathematical Model to a Technology, the 100 Years’ Evolution of PBPK
2. Basic principles of PBPK modeling and simulation
3. Oral Drug absorption in special populations: in vivo – in vitro – in silico evaluation
4. Physiologically based absorption models for complex formulations and dosage forms
5. Perfusion and permeability-limited distribution models
6. Modeling drug metabolism and excretion
7. Platform Qualification and Model verification
8. Applying PBPK modeling to predict drug-drug interactions
9. Applying PBPK modeling to predict drug exposure in special populations
10. PBPK-based Virtual Bioequivalence Trials to Guide Drug Development
11. Application of PBPK modeling to support clinical pharmacology regulatory decision-making
12. Physiologically based biopharmaceutics modeling (PBBM) in support of drug product specifications and biowaiver
13. Integrating PBPK modeling and Organ-on-a-chip systems to inform drug development