Synthesis and antimicrobial activity of Phthalimide derivatives

Antimicrobial activity of new molecules
Erscheinungsjahr 2012
ISBN: 978-3-8454-1838-4
Verlag: LAP Lambert Academic Publishing

Buch, Englisch, 108 Seiten, Paperback, Format (B × H): 150 mm x 220 mm, Gewicht: 179 g

A series of novel phthalimide derivatives (SV 1-8) have been synthesized and evaluated for antimicrobial activity. The target compounds were prepared by fusion of glycine with phthalic anhydride at 150-155 ºC to afford 2-(1, 3- dioxoisoindolin-2-yl) acetic acid. The compound 2-(1, 3-dioxoisoindolin-2-yl) acetic acid was treated with thionyl chloride in chloroform to afford 2-(1, 3-dioxoisoindolin-2-yl) acetyl chloride which was further treated with substituted phenols in presence of anhydrous potassium carbonate in dry acetone yielded the final compounds (SV1-8). The structures of the target compounds were characterized on the basis of their m.p., TLC, IR and 1H-NMR data. All the target compounds were evaluated for antibacterial and antifungal activity.

Autoren/Hrsg.

Saleem, Shakir

Alam, Jahangir

Kazmi, Imran

Über Autor(innen)

I am research scholar in Jamia Hamdard, New Delhi. At only B. Pharm level i have got academic excellence. I have many research papers on Elsevier (Science Direct)including Journal of Ethnopharmacol, Fitoterapia, Life Sciences etc. with cumulative Impact factor greater than 10. I am expert in HPLC and animal handling.