Buch, Englisch, 815 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 13784 g
Buch, Englisch, 815 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 13784 g
ISBN: 978-3-319-79387-0
Verlag: Springer International Publishing
The author explains that there is no such evidence that “malignantly transformed” human cells survive in nature. However, when cared for in the laboratory, these cells live and replicate as immortalized cultures. These cells retain their vitality upon storage in liquid nitrogen. One can only imagine an astrophysical environment in which such cells could survive; perhaps, first their seemingly humble exosomes would populate that environment. Immortal cell populations so created may survive as individuals, or may even re-organize themselves into multicellular colonies, as representatives of life for the duration of the Universe.
This thought-provoking book is the work of a disciplined investigator and clinician with an impeccable reputation, and he enters a territory that very few if any before him have approached from the same angles. It will appeal to researchers with an interest in cell survival pathways and those researching cancer cells.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
Weitere Infos & Material
Preface. Introductions. I THE PRIMORDIAL RNA/DNA COMPLEX EVOLVING.- The Primordial Genes Are Conserved as Stem Cell Genes and Proto-Oncogenes.- The First Cells Ascend.- Eukaryotic Single Cells and the First Cell Communities Then and Now.- A Highly Effective Immune System Predating Adaptive Immunity.- Elements of Adaptive Immunity Self-Assemble.- The RNA/DNA Complex at Work.- YY Proteins.- Elusive Alleles.- The Long Trajectory of the IGF-like Receptor and Its Ligands.- Primordial Fused Genes Become Oncogenes and Encode Oncoproteins.- Performance in the Laboratory.- Inbuilt Errors not yet Corrected.- Errors or Inherent Attributes for the Sustenance of Unicellular Life.- Viral Genomic Insertions into the Host Cell’s Genome.- Viral and Cellular Proteins Interact.- Light Cast to Broken DNA, Its Repair, and Consequences.- Undisciplined Introns.- Elementary Epigenomics.- RNA/DNA: Bioengineers Supreme.- II THE ONCOGENOME.- Seamless Unity of the Nucleus and Cytoplasm: the Membranes Are Permeable.- Endogenously Initiated Immortalization is Welcome. Enforced Carcinogenesis by Exogenous Alien Initiator Is Resisted.- A Condensed Compendium.- “Malignant Transformation”.- III THE HUMAN CEREBRAL CORTICAL DNA AGAINST CANCER CELL DNA.- Will the Human Cerebral Cortex Subdue the Oncogenome?- In Self-Defense, the Cancer Cell Reactivates Its Primordial Genome Loaded with Proviruses in Order to Mobilize All Its Remaining Survival Pathways.- The Cancer Cell Viewed as a Unicellular Parasite (an Amoeba).- Astute Observers Withstand Derision.- “Making Cancer History” at M.D. Anderson Hospital.- SUMMARY.- Appendix 1.-Appendix 2.- Index.