Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Models in Discovery and Translation
Erscheinungsjahr 2013
ISBN: 978-0-12-416004-0
Verlag: William Andrew Publishing

Buch, Englisch, 536 Seiten, Format (B × H): 216 mm x 276 mm, Gewicht: 1720 g

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future.

Allogeneic HSCT is a medical procedure in which a patient receives blood-forming stem cells from a genetically similar but not identical donor. This procedure is commonly performed for people with diseases of the blood, bone marrow, or certain cancers, but it remains risky with many possible complications. As such, experimental practice is reserved for preclinical animal models including the mouse and dog.

These animal models have been essential in developing transplant protocols, including preclinical testing of conditioning regimens, treatment of GVHD, and understanding the pathology of GVHD as well as the immunological mechanisms of GVHD and GVL effect. However, recent research has revealed significant species differences between humans and animal models that must be considered when relating animal model studies to clinical allogeneic HSCT scenarios.

Zielgruppe

stem cell biologists, cancer biologists, immunologists, hematologists, cardiologists, oncologists, pathologist</p>

Autoren/Hrsg.

Socie, Gerard

Blazar, Bruce R.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Hämatologie, Transfusionsmedizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Kardiologie, Angiologie, Phlebologie

Inhaltsverzeichnis

Overview of the immune biology of HSCT; The HLA system; Minor Histocompatibility antigens; In vivo imaging of GVHD and GVL; Immune rejection; The basis of immune deficiency; Tumor associated antigens; Impact of the conditioning regimen; Dendritic cells in GVHD; Costimulatory molecules in GVHD and GVL; Conventional T cells in GvHD and GVL; Regulatory T cells in GVHD and GVL; Th17 in GVHD and GVL; B cells in GVHD and GVL; Cytokines in GVHD and GL; Chemokines in GVHD and GL; Intracellular sensors; Proteomics in GVHD and GVL; The endothelium in GVHD and GVL; Immune Biology of the future

Über Autor(innen)

Socie, Gerard
Dr. Gerard Socie's main field of expertise (clinical and biological); allogeneic stem cell transplantation with special focus on graft-versus-host disease and study of late effects, aplastic anemia with special focus on PNH, and Fanconi anemia. He is GCP certified (last May 2017) and the department head and head of transplantation at the Hospital Saint Louis, University of Paris VII.