Audenaert / Overvoorde Plant Chemical Biology

1. Auflage 2013
ISBN: 978-1-118-74317-1
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 312 Seiten, E-Book

Demonstrates how advances in plant chemical biology cantranslate to field applications
With contributions from a team of leading researchers andpioneers in the field, this book explains how chemical biology isused as a tool to enhance our understanding of plant biology.Readers are introduced to a variety of chemical biology studiesthat have provided novel insights into plant physiology and plantcellular processes. Moreover, they will discover that chemicalbiology not only leads to a better understanding of the underlyingmechanisms of plant biology, but also the development of practicalapplications. For example, the authors discuss small molecules thatcan be used to identify targets of herbicides and develop newherbicides and plant growth regulators.
The book begins with a historical perspective on plant chemicalbiology. Next, the authors introduce the chemical biology toolboxneeded to perform successful studies, with chapters covering:
* Sources of small molecules
* Identification of new chemical tools by high-throughputscreening (HTS)
* Use of chemical biology to study plant physiology
* Use of chemical biology to study plant cellular processes
* Target identification
* Translation of plant chemical biology from the lab to thefield
Based on the latest findings and extensively referenced, thebook explores available compound collections, principles of assaydesign, and the use of new research tools for the development ofnew applications.
Plant Chemical Biology is recommended for students andprofessionals in all facets of plant biology, including molecularbiology, physiology, biochemistry, agriculture, horticulture, andagronomy. All readers will discover new approaches that can lead tothe development of a healthier and more plentiful global foodsupply.

Autoren/Hrsg.

Audenaert, Dominique

Overvoorde, Paul

Inhaltsverzeichnis

Preface vii
Contributors ix
part one Introduction 1
1.1 From Herbal Remedies to Cutting-Edge Science: A HistoricalPerspective of Plant Chemical Biology 3
Michelle Q. Brown, Abel Rosado, and Natasha V. Raikhel
part Two Sources of small molecules 19
2.1 Compound Collections 21
Reg Richardson
2.2 Combinatorial Chemistry Library Design 40
Robert Klein and Stephen D. Lindell
2.3 Natural Product-Based Libraries 64
Alan L. Harvey
part three Identification of new chemical tools byHigh-Throughput Screening 73
3.1 Assay Design for High-Throughput Screening 75
Frank W. An and Jose R. Perez
part four Use of chemical biology to study plant physiology93
4.1 Use of Chemical Biology to Understand Auxin Metabolism,Signaling, and Polar Transport 95
Ken-ichiro Hayashi and Paul Overvoorde
4.2 Brassinosteroids Signaling and Biosynthesis 128
Takeshi Nakano and Tadao Asami
4.3 Chemical Genetic Approaches on ABA Signal Transduction145
Eunjoo Park and Tae-Houn Kim
4.4 Jasmonic Acid 160
Christian Meesters and Erich Kombrink
4.5 Chemical Genetics as a Tool to Study Ethylene Biology inPlants 184
Yuming Hu, Filip Vandenbussche, and Dominique Van DerStraeten
part five Use of chemical biology to study plant cellularprocesses 203
5.1 The Use of Small Molecules to Dissect Cell Wall Biosynthesisand Manipulate the Cortical Cytoskeleton 205
Darby Harris and Seth DeBolt
5.2 The Use of Chemical Biology to Study Plant CellularProcesses: Subcellular Trafficking 218
Ash Haeger, Malgorzata £angowska, and StéphanieRobert
part six Target identification 233
6.1 Target Identification of Biologically Active Small Molecules235
Paul Overvoorde and Dominique Audenaert
part seven Translation of plant chemical biology from the labto the field 247
7.1 Prospects and Challenges for Translating Emerging Insightsin Plant Chemical Biology into New Agrochemicals 249
Terence A. Walsh
7.2 In Vitro Propagation 263
Hans Motte, Stefaan Werbrouck, and Danny Geelen
Index 289

Über Autor(innen)

DOMINIQUE AUDENAERT, PhD, works in the VIB CompoundScreening Facility at Ghent University. His research expertiseincludes assay development, compound screening, and chemicalbiology research.
PAUL OVERVOORDE, PhD, executes his research and teachingactivities at Macalester College (St. Paul, MN), where he is aprofessor of biology. He has a longstanding interest in definingthe role of auxin-mediated gene expression during plantdevelopment.