Batinic-Haberle / Batinic-Haberle / Rebouças Redox-Active Therapeutics

1. Auflage 2016
ISBN: 978-3-319-30705-3
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: Wasserzeichen (»Systemvoraussetzungen)

E-Book, Englisch, 694 Seiten, eBook

Reihe: Oxidative Stress in Applied Basic Research and Clinical Practice

This essential
volume comprehensively discusses redox-active therapeutics, focusing
particularly on their molecular design, mechanistic, pharmacological and
medicinal aspects.  The first section of the book describes the basic
aspects of the chemistry and biology of redox-active drugs and includes a brief
overview of the redox-based pathways involved in cancer and the medical aspects
of redox-active drugs, assuming little in the way of prior knowledge.
Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative
diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head
and neck and erectile function) and neglected diseases (e.g., leishmaniasis).
It encompasses several major classes of redox-active experimental therapeutics, which
include porphyrins, salens, nitrones, and most notably metal-containing (e.g.,
Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with
nanomaterials and quantum dots. Numerous illustrations, tables
and figures enhance and complement the text; extensive references to relevant
literature are also included.
 
Redox-Active Therapeutics
is an invaluable addition to Springer’s
Oxidative
Stress in Applied Basic Research and Clinical Practice
 series.
 It is essential reading for researchers, clinicians and graduate students
interested in understanding and exploring the Redoxome—the organism redox
network—as an emerging frontier in drug design, redox biology and medicine.

Zielgruppe

Research

Autoren/Hrsg.

Batinic-Haberle, Ines

Rebouças, Júlio S.

Spasojevic, Ivan

Inhaltsverzeichnis

Part
1. Pathophysiological Roles of Superoxide Dismutases (SOD).- Superoxide and the
Superoxide Dismutases: An Introduction by Irwin Fridovich.- The Discovery of
Superoxide Dismutase and Its Role in Redox Biology.- Manganese Superoxide
Dismutase (MnSOD) and It's Importance in Mitochondrial Function and Cancer.- Regulation
of the Cellular Redox Environment by Superoxide Dismutases, Catalase and Glutathione
Peroxidases During Tumor Metastasis.- Superoxide Dismutase Family of Enzymes in
Brain Neurogenesis and Radioprotection.- Metabolic Production of H
2
O
2
in Carcinogenesis and Cancer Treatment.- Part 2. Redox-Active Therapeutics –
Design and Mechanisms of Action.- Mimicking SOD, Why and How: Bio-Inspired
Manganese Complexes as SOD Mimics.- Mn Porphyrin-Based Redox-Active
Therapeutics.- Cytochrome P450-like Biomimetic Oxidation Catalysts Based on Mn
porphyrins as Redox Modulators.- Nitrones as Potent Anticancer Therapeutics.- Salen
Manganese Complexes Mitigate Radiation Injury in Normal Tissues Through
Modulation of Tissue Environment.- Molecular Basis for Anticancer and Antiparasite
Activities of Copper-Based Drugs.- Small Signaling Molecules and CO-Releasing
Molecules (CORMs) for the Modulation of the Cellular Redox Metabolism.- HNO/Thiol
Biology as a Therapeutic Target.- Part 3. Redox-Active Therapeutics in Cancer.-
Advances in Breast Cancer Therapy Using Nitric Oxide and Nitroxyl Donor Agents.-
Mechanisms by Which Manganese Porphyrins Affect Signaling in Cancer Cells.- Targeted
Therapy for Malignant Brain Tumors.- Redox Therapeutics in Breast Cancer: Role of
SOD Mimics.- Anticancer Action of Mn porphyrins in Head and Neck Cancers.- Redox-based
Therapeutic Strategies in the Treatment of Skin Cancers.- Role of Oxidative Stress
in Erectile Dysfunction after Prostate Cancer Therapy.- Theranostic Nanoconjugates
of Tetrapyrrolic Macrocycles and Their Applications in Photodynamic Therapy.-
Part 4. Redox-Active Therapeutics in Other Diseases.- QuantumDots in
Photodynamic Therapy.- Metalloporphyrins in CNS injuries.- The Contribution of Nitroxidative
Stress to Pathophysiological Pain and Opioid Analgesic Failure.- Amyotrophic
Lateral Sclerosis – Present Understanding of the Role of SOD.- Redox Regulation
and Misfolding of SOD1: Therapeutic Strategies for Amyotrophic Lateral
Sclerosis.- Redox-Based Therapeutics for Prevention
,
Mitigation,
and Treatment of Lung Injury Secondary to Radiation Exposure.- Using Metalloporphyrins
to Preserve

ß

Cell Mass and Inhibit Immune Responses in Diabetes.-
Redox-Active Metal Complexes in Trypanosomatids.

Über Autor(innen)

INES BATINIC-HABERLE,
PhD
Ines Batinic-Haberle is a Professor of Radiation
Oncology at the Department of Radiation Oncology, Duke University School of
Medicine. She received her B.Sc. in Food Chemistry, M.Sc. degree in Analytical
Chemistry, and her Ph.D. degree in Bioinorganic Chemistry from the School of
Pharmacy and Biochemistry, University of Zagreb, Croatia. She completed her
postdoctoral education at the Department of Chemistry, Duke University. She then
moved to the Department of Biochemistry at Duke University School of Medicine,
where she was trained by Irwin Fridovich, the Father of the field of
Free Radicals in Biology and Medicine.
She
spent 10 years in Fridovich’s Lab where she acquired the basis of her expertise
in
Oxidative Stress
and
Redox-Active Therapeutics
and launched
the design of powerful Mn porphyrin-based SOD mimics.  She established the structure-activity
relationship for Mn porphyrin-based SOD mimics, which she subsequently extended
to all classes of SOD mimics. She holds a number of compositional and methods
of use patents on metalloporphyrins; her lead compounds are either already in
or entering Clinical Trials in 2016. She authored more than 190 manuscripts,
several book chapters, has served as Guest/Invited Editor and reviewer of
various prestigious journals and granting agencies both nationally and internationally.
For the last 6 years she has served as a
Society
for Redox Biology and Medicine
(SFRBM) Officer and is a founding member of
the
Society of Porphyrins and
Phthalocyanines
. She was recently awarded the SFRBM Excellence in Mentoring
Award. She has organized numerous Symposia nationally and internationally and
gave lectures at numerous Universities in the USA and abroad. She has
established numerous collaborations with research groups in USA and
internationally and worked actively in advancing metalloporphyrins towards
clinic.
JULIO S. REBOUCAS, PhD
Julio
S. Reboucas is an Adjunct Professor at Universidade Federal da Paraiba (UFPB,
Brazil), Adjunct Head of the UFPB Chemistry Graduate Programs, and Fellow of
the Brazilian National Research Council (CNPq). He received his Chemical
Engineering B.Sc. and Chemistry M.Sc. degrees from Universidade Federal de Minas
Gerais (Brazil) and his Chemistry Ph.D. degree from the University of British
Columbia (Canada). He joined the Batinic-Haberle and Spasojevic Laboratories at
Duke University (USA) in 2006, where he completed his postdoctoral training in oxidative
stress and porphyrin-based redox-active therapeutics, before moving to UFPB in
2009 to establish an accredited porphyrin research group. His research spans
the fields of medicinal and inorganic chemistry, with emphasis on
porphyrin-based biomimetic systems. He has co-authored 52 manuscripts, two book
chapters, and has one patent application. He is a founding member of the
Society of Porphyrins and Phthalocyanines
and currentlyserves as the elected Inorganic Chemistry Division secretary of
the
Brazilian Chemical Society
. Among
his honors and awards is receiving the Young Investigator Award by the
Society for Redox Biology and Medicine
. He
has collaborated with various groups within Brazil and abroad on porphyrin
chemistry and medicine.
 IVAN SPASOJEVIC, PhD
Ivan Spasojevic
is an Assistant Professor of Medicine at the Department of Medicine, Division
of Oncology. He is also a Director of the PK/PD Core Lab of Duke Cancer
Institute Pharmaceutical Research Shared Resource, an NCI-supported
state-of-the-art bioanalytical facility providing study design and modeling
expertise in pharmacokinetics/pharmacodynamics (PK/PD) and performing analysis
of drugs and their metabolites, oxidative stress markers and other small
biomolecules in general. His Lab has provided the invaluable support in the
development of Mn porphyrins towards Clinical Trials. Ivan earned his B.Sc.
degree in Chemical Engineering from the School of Chemical Engineering, Zagreb,
Croatia and his Ph.D. Degree in Bioinorganic Chemistry from the Department of
Chemistry, Duke University. He completed his postdoctoral training with Irwin
Fridovich in the field of
Oxidative stress
and
Free Radicals in
Biology and Medicine
and started his work on the design of Mn
porphyrin-based SOD mimics. He has co-authored 126 manuscripts including
several Book Chapters, has several compositional and method of use patents and
patent applications. He has served as Guest/Invited Editor and reviewer of
various prestigious journals and was invited speaker/organized symposia at National
and International Meetings. He is a founding member of the
Society of
Porphyrins and Phthalocyanines
. He has collaborated with numerous groups in
and outside of USA in the field of drug development and pharmacokinetics.